Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK17B | O94768 | 1/20 | 0.39 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 3/20 | 0.36 |
| ▸ | BTK | Q06187 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.35 |
| ▸ | JAK3 | P52333 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | DRD5 | P21918 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15056902 | 0.84 | STK17B (0.51) | STK17BSTK17ADRD2PRMT5DRD3 | |
| SCHEMBL16337923 | 0.84 | STK17B (0.51) | STK17BSTK17ADRD2PRMT5DRD3 | |
| SCHEMBL16336962 | 0.84 | STK17B (0.51) | STK17BSTK17ADRD2PRMT5DRD3 | |
| SCHEMBL18440370 | 0.81 | TNK2 (0.39) | STK17BSTK17AGRM5BTKLRRK2 | |
| SCHEMBL16336972 | 0.81 | STK17B (0.50) | STK17BSTK17ADRD2PRMT5DRD3 | |
| SCHEMBL16336181 | 0.81 | STK17B (0.50) | STK17BSTK17ADRD2PRMT5DRD3 | |
| SCHEMBL15055509 | 0.81 | STK17B (0.50) | STK17BSTK17ADRD2PRMT5DRD3 | |
| SCHEMBL28814728 | 0.78 | TNK2 (0.38) | STK17BSTK17AGRM5BTK | |
| SCHEMBL27987039 | 0.78 | TNK2 (0.38) | STK17BSTK17AGRM5BTK | |
| SCHEMBL27987045 | 0.78 | TNK2 (0.38) | STK17BSTK17AGRM5BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2794598-A1 | PYRIMIDINE-2,4-DIAMINE DERIVATIVES AS KINASE INHIBITORS | Cellzome Limited (GB) | 2014-10-29 | — | — | EP | disclosed |
| WO-2013092854-A1 | PYRIMIDINE-2,4-DIAMINE DERIVATIVES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2013-06-27 | — | — | WO | disclosed |