Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 18/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15057556 | 0.87 | ALDH1A1 (0.54) | ALDH1A1TSHRCYP1A2CYP3A4RAB9A | |
| SCHEMBL31412924 | 0.86 | ALDH1A1 (0.57) | ALDH1A1TSHRCYP1A2CYP3A4RAB9A | |
| SCHEMBL31412931 | 0.86 | ALDH1A1 (0.57) | ALDH1A1TSHRCYP1A2CYP3A4RAB9A | |
| SCHEMBL2063172 | 0.86 | ALDH1A1 (0.57) | ALDH1A1TSHRCYP1A2CYP3A4RAB9A | |
| SCHEMBL2176399 | 0.85 | ALDH1A1 (0.62) | ALDH1A1TSHRCYP1A2CYP3A4RAB9A | |
| SCHEMBL21200929 | 0.80 | ALDH1A1 (0.58) | ALDH1A1TSHRCYP1A2CYP3A4RAB9A | |
| SCHEMBL29487159 | 0.78 | ALDH1A1 (0.62) | ALDH1A1TSHRCYP1A2CYP3A4RAB9A | |
| SCHEMBL6250003 | 0.78 | ALDH1A1 (0.62) | ALDH1A1TSHRCYP1A2CYP3A4RAB9A | |
| SCHEMBL25417473 | 0.77 | ALDH1A1 (0.65) | ALDH1A1TSHRCYP1A2CYP3A4RAB9A | |
| SCHEMBL15578394 | 0.77 | ALDH1A1 (0.65) | ALDH1A1TSHRCYP1A2CYP3A4RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150148377-A1 | Quinoline Derivatives | NOVARTIS AG (CH) | 2015-05-28 | — | — | US | disclosed |
| US-20150148377-A1 | Quinoline Derivatives | NOVARTIS AG (CH) | 2015-05-28 | — | — | US | disclosed |
| US-20150148377-A1 | Quinoline Derivatives | NOVARTIS AG (CH) | 2015-05-28 | — | — | US | disclosed |
| EP-2794594-A1 | QUINOLINE DERIVATIVES | Novartis AG (CH) | 2014-10-29 | — | — | EP | disclosed |
| WO-2013093850-A1 | QUINOLINE DERIVATIVES | NOVARTIS AG (CH) | 2013-06-27 | — | — | WO | disclosed |
| WO-2013093850-A1 | QUINOLINE DERIVATIVES | NOVARTIS AG (CH) | 2013-06-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150148377-A1 | Quinoline Derivatives | RECQL, NQO2, PIK3R3 | ALDH1A1 2856/4885TSHR 2027/4885CYP1A2 230/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.