Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | HTT | P42858 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | RAB9A | P51151 | 4/20 | 0.62 |
| ▸ | NPC1 | O15118 | 3/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.59 |
| ▸ | HTR3B | O95264 | 2/20 | 0.59 |
| ▸ | HTR3A | P46098 | 2/20 | 0.59 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.59 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | F13A1 | P00488 | 1/20 | 0.54 |
| ▸ | TGM2 | P21980 | 1/20 | 0.54 |
| ▸ | FADS1 | O60427 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | IDO1 | P14902 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1184744 | 0.93 | HTR3E (0.61) | MEN1KMT2AMAPTLMNAHTT | |
| Hydrochloric Acid SCHEMBL3612283 | 0.91 | HTR3E (0.59) | MEN1KMT2AMAPTLMNAHTT | |
| Nitric Acid SCHEMBL2862594 | 0.85 | MAPT (0.53) | MEN1KMT2AMAPTLMNAHTT | |
| Nitric Acid SCHEMBL7234512 | 0.85 | MAPT (0.53) | MEN1KMT2AMAPTLMNAHTT | |
| SCHEMBL167193 | 0.82 | MEN1 (0.71) | MEN1KMT2AMAPTLMNAHTT | |
| Ammonia Solution, Strong SCHEMBL28790660 | 0.80 | MEN1 (0.69) | MEN1KMT2AMAPTLMNAHTT | |
| SCHEMBL4108214 | 0.80 | MEN1 (0.59) | MEN1KMT2AMAPTLMNAHTT | |
| SCHEMBL2094553 | 0.80 | MEN1 (0.74) | MEN1KMT2AMAPTLMNAHTT | |
| SCHEMBL1884170 | 0.80 | MEN1 (0.74) | MEN1KMT2AMAPTLMNAHTT | |
| SCHEMBL1229884 | 0.79 | HTR3E (0.54) | MEN1KMT2AMAPTLMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013092460-A1 | CYCLIC BISOXIME MICROBICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2013-06-27 | — | — | WO | disclosed |
| CN-1446048-A | N-phenyl-4- (4-pyridyl) -2-pyrimidinamine derivatives | SYNGENTA PARTICIPATIONS AG (CH) | 2003-10-01 | — | — | CN | disclosed |