HTR3E

5-hydroxytryptamine receptor 3E (5-HT3-E) (5- · A5X5Y0 · HTR3E on Sugi Atlas →

71,076 patent compounds predicted against HTR3E, 47,933 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Tropisetron (SCHEMBL18297)	1.00	7/20
Tropisetron (SCHEMBL18299)	1.00	7/20
Tropisetron (SCHEMBL133873)	0.98	7/20
Dolasetron (SCHEMBL42063)	0.72	7/20
Dolasetron (SCHEMBL42064)	0.72	7/20
Dolasetron (SCHEMBL42065)	0.72	7/20
Dolasetron (SCHEMBL41145)	0.65	7/20
Dolasetron (SCHEMBL41146)	0.65	7/20
Mirisetron (SCHEMBL194840)	0.59	7/20
Mirisetron (SCHEMBL194841)	0.59	7/20
Mirisetron (SCHEMBL121861)	0.55	6/20
Mirisetron (SCHEMBL121862)	0.55	6/20
Phenylpiperazine (SCHEMBL24889)	1.00	5/20
Phenylpiperazine (SCHEMBL55125)	1.00	5/20
SCHEMBL166140	1.00	5/20
SCHEMBL232655	0.61	5/20
SCHEMBL59331	0.61	5/20
SCHEMBL164098	0.56	5/20
SCHEMBL221254	0.55	5/20
Noxiptiline (SCHEMBL49824)	0.52	5/20

Clinical trials — most relevant to HTR3E by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
The Relationship Among Changes in Brain Network Activation in Adult Outpatients With Major Depressive Disorder	PHASE4	COMPLETED
Clinical Neurobiology of Serotonin and Addiction	PHASE2/PHASE3	COMPLETED
Study to Evaluate AD04 in Adults With Alcohol Use Disorder (AUD) and Selected Serotonin Transporter Polymorphisms	PHASE3	COMPLETED
Continuous Infusion of First-Generation 5-HT3 Receptor Antagonists in Combination With Dexamethasone	PHASE3	COMPLETED
Prophylaxis Against Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy	PHASE2	UNKNOWN
5HT2CR Balance in Brain Connectivity in Cocaine Dependence	PHASE1/PHASE2	COMPLETED
Safety and Efficacy of MEM 3454 Versus Placebo in Patients With Mild to Moderate Alzheimer's Disease	PHASE2	COMPLETED
Trastuzumab Deruxtecan in First-Line HER2-Positive Metastatic Breast Cancer With Proactive Toxicity Management	PHASE2	RECRUITING
The Effect of Ginger on the Incidence of Postoperative Nausea and Vomiting	PHASE2	COMPLETED
Psilocybin With Pimavanserin Compared to Psilocybin Alone for the Treatment of Major Depressive Disorder	PHASE2	RECRUITING
Psilocybe Cubensis Mushrooms With or Without Fluoxetine for Refractory Depression	PHASE1/PHASE2	RECRUITING
The Neurobiological Effect of 5-HT2AR Modulation	PHASE1	RECRUITING
PET Imaging of Brain 5-HT(1A) Receptors Using [(11)C](-)-RWAY	PHASE1	COMPLETED
SRC Inhibition as a Potential Target for Parkinson's Disease Psychosis	EARLY_PHASE1	UNKNOWN
The Efficacy of Tianeptine Versus Pregabalin on Acute and Chronic Post Mastectomy Pain After Breast Cancer Surgery.	nan	COMPLETED
The Pill Project - Oral Contraceptive and Serotonergic Brain Signaling	nan	UNKNOWN
Evaluation of [11C]Cimbi-36 as an Agonist PET Radioligand for Imaging of 5-HT2A Receptors	nan	COMPLETED
Intern Health Study	nan	ENROLLING_BY_INVITATION
Genetic Variants Associated With Adolescent Suicide Attempts	nan	COMPLETED
The Role of 5-HT2A Receptor in the Perception of Self and Personal Meaning in Healthy Volunteers	nan	COMPLETED
The Role of Sex Steroids and Serotonin Brain Dynamics in Perinatal Mental Health	nan	COMPLETED
5-HT7 Receptor Implication in Inflammatory Mechanisms in Multiple Sclerosis	nan	COMPLETED
Trazodone and the Risk of Serious Adverse Events	nan	COMPLETED
Investigating Serotonin Signalling in IBD Patients	nan	RECRUITING
Epigenetic and Neurochemical Correlates of Bipolar Disorder	nan	NOT_YET_RECRUITING
Development of A Technique to Predict Antidepressant Responsiveness in Depressive Patients	nan	UNKNOWN
Examination of Brain Serotonin Receptors in Patients With Mood Disorders	nan	COMPLETED
Investigation of Serotonin Neurotransmission in MDMA Users Using Combinated Dexfenfluramine Challenge and PET Imaging	nan	COMPLETED
Imaging Serotonin 5HT1A Receptors in Patients With Major Depressive Disorder	nan	WITHDRAWN
TSK (Tryptophan - Serotonin - Kynurenine) Biomarkers Assessment in Stroke	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a HTR3E binder may also engage these)

Protein	Name	Similarity
HTR3C	5-hydroxytryptamine receptor 3C (5-HT3-C) (5-	0.992	landscape →
HTR3B	5-hydroxytryptamine receptor 3B	0.976	landscape →
O70212	—	0.969	O70212 →
P23979	—	0.968	P23979 →
HTR3A	5-hydroxytryptamine receptor 3A	0.968	landscape →
P35563	—	0.962	P35563 →
Q9JHJ5	—	0.957	Q9JHJ5 →
Q9JJ16	—	0.957	Q9JJ16 →
CHRNG	Acetylcholine receptor subunit gamma	0.953	landscape →
P18916	—	0.952	P18916 →
P13536	—	0.951	P13536 →
P04760	—	0.949	P04760 →
P25109	—	0.948	P25109 →
CHRNB1	Acetylcholine receptor subunit beta	0.944	landscape →
P02713	—	0.943	P02713 →
P09660	—	0.940	P09660 →
P09690	—	0.939	P09690 →
P04758	—	0.936	P04758 →
P20782	—	0.934	P20782 →
P02715	—	0.931	P02715 →
HTR3D	5-hydroxytryptamine receptor 3D (5-HT3-D) (5-	0.931	landscape →
Q9R1N2	—	0.931	Q9R1N2 →
Q61180	—	0.931	Q61180 →
O97741	—	0.930	O97741 →
Q9P0L9	—	0.927	Q9P0L9 →
P04759	—	0.926	P04759 →
P37089	—	0.925	P37089 →
CHRNE	Acetylcholine receptor subunit epsilon	0.925	landscape →
Q14246	—	0.923	Q14246 →
CHRND	Acetylcholine receptor subunit delta	0.923	landscape →