Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.36 |
| ▸ | BRD1 | O95696 | 1/20 | 0.36 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4690120 | 0.99 | DRD2 (0.43) | DRD2DRD3KCNH2PIK3C3GAA | |
| SCHEMBL15061278 | 0.87 | KDM2B (0.48) | DRD2DRD3PIK3C3GAAKMT2A | |
| Hydrochloric Acid SCHEMBL4690124 | 0.86 | KDM2B (0.48) | DRD2DRD3PIK3C3GAAKMT2A | |
| SCHEMBL4686814 | 0.83 | KMT2A (0.57) | DRD2DRD3KCNH2GAAKMT2A | |
| SCHEMBL4688575 | 0.83 | DRD2 (0.45) | DRD2DRD3KCNH2KMT2AHTR6 | |
| SCHEMBL15061210 | 0.82 | NMT1 (0.51) | KCNH2PIK3C3GAAKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL4690752 | 0.81 | NMT1 (0.50) | KCNH2PIK3C3GAAKMT2AMEN1 | |
| SCHEMBL4686850 | 0.79 | DRD2 (0.52) | DRD2DRD3KCNH2GAAKMT2A | |
| SCHEMBL15061250 | 0.79 | KMT2A (0.41) | DRD2DRD3GAAKMT2AMEN1 | |
| SCHEMBL15061187 | 0.79 | DRD2 (0.48) | DRD2DRD3KCNH2HTR6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8476275-B2 | N-[piperazinyl hetaryl]arylsufonamide compounds with affinity for the dopamine D3 receptor | ABBOTT GMBH & CO. KG (DE) | 2013-07-02 | — | — | US | claimed |