Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.37 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.37 |
| ▸ | SCN4A | P35499 | 1/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15351714 | 0.89 | TAAR1 (0.48) | MAOBTAAR1 | |
| SCHEMBL1044946 | 0.89 | TAAR1 (0.48) | MAOBTAAR1 | |
| SCHEMBL15352287 | 0.89 | TAAR1 (0.48) | MAOBTAAR1 | |
| SCHEMBL15352076 | 0.89 | TAAR1 (0.48) | MAOBTAAR1 | |
| SCHEMBL15351748 | 0.89 | TAAR1 (0.48) | MAOBTAAR1 | |
| SCHEMBL8550992 | 0.89 | TAAR1 (0.48) | MAOBTAAR1 | |
| SCHEMBL15353066 | 0.89 | TAAR1 (0.48) | MAOBTAAR1 | |
| SCHEMBL1047350 | 0.87 | TAAR1 (0.50) | MAOBTAAR1 | |
| SCHEMBL7386173 | 0.85 | LTA4H (0.51) | LTA4HEPHX2MAOBTAAR1SOS1 | |
| SCHEMBL15061351 | 0.85 | MAOB (0.59) | LTA4HEPHX2MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8476302-B2 | α-ketoamide derivatives useful endothelial lipase inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 2013-07-02 | — | — | US | claimed |