SCHEMBL15061815

SCHEMBL15061815

CCOC1CC(n2cc(C#CCNC(=O)C(F)(F)F)c(=O)[nH]c2=O)OC1CO[Si](C)(C)C(C)(C)C

nearest known ligand 0.48

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TOP2A P11388 4/20 0.43
HDAC1 Q13547 3/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18844509 0.93 TOP2A (0.43) TOP2AHDAC1
SCHEMBL20953734 0.93 TOP2A (0.43) TOP2AHDAC1
SCHEMBL18855349 0.92 TOP2A (0.42) TOP2AHDAC1
SCHEMBL2128874 0.92 TOP2A (0.42) TOP2AHDAC1
SCHEMBL2128870 0.92 TOP2A (0.42) TOP2AHDAC1
SCHEMBL18855391 0.92 TOP2A (0.42) TOP2AHDAC1
SCHEMBL18844492 0.92 TOP2A (0.42) TOP2AHDAC1
SCHEMBL12047224 0.92 TOP2A (0.42) TOP2AHDAC1
SCHEMBL20974279 0.92 TOP2A (0.43) TOP2AHDAC1
SCHEMBL2148407 0.91 TOP2A (0.41) TOP2AHDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2607369-A1 Modified nucleotides for polynucleotide sequencing Illumina Cambridge Limited (GB) 2013-06-26 EP disclosed