Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.51 |
| ▸ | SCD | O00767 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 3/20 | 0.48 |
| ▸ | HTR2B | P41595 | 3/20 | 0.48 |
| ▸ | NOS3 | P29474 | 1/20 | 0.47 |
| ▸ | NOS1 | P29475 | 1/20 | 0.47 |
| ▸ | NOS2 | P35228 | 1/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.47 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10260949 | 1.00 | PDE10A (0.51) | PDE10ASCDHTR2CHTR2BNOS3 | |
| SCHEMBL10260935 | 1.00 | PDE10A (0.51) | PDE10ASCDHTR2CHTR2BNOS3 | |
| SCHEMBL10274501 | 0.91 | SCD (0.53) | PDE10ASCDCHRM4CHRM5CHRM1 | |
| SCHEMBL30656257 | 0.91 | SCD (0.53) | PDE10ASCDCHRM4CHRM5CHRM1 | |
| SCHEMBL10260948 | 0.87 | SLC6A4 (0.44) | PDE10ASCDCHRM4CHRM3 | |
| SCHEMBL14578204 | 0.84 | HTR2C (0.53) | HTR2CHTR2BNOS3NOS1NOS2 | |
| SCHEMBL10261314 | 0.81 | HTR2C (0.51) | HTR2CHTR2BNOS3NOS1NOS2 | |
| SCHEMBL1927488 | 0.81 | UTS2R (0.51) | HTR2CHTR2BNOS3NOS1NOS2 | |
| SCHEMBL15651062 | 0.81 | NOS3 (0.52) | HTR2CHTR2BNOS3NOS1NOS2 | |
| SCHEMBL10260926 | 0.81 | HTR2C (0.51) | HTR2CHTR2BNOS3NOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2607364-A1 | Tetraaza-cyclopenta[a]indenyl and their use as positive allosteric modulators | Ares Trading S.A. (CH) | 2013-06-26 | — | — | EP | disclosed |