Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | YEATS4 | O95619 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10236279 | 0.77 | MAPK1 (0.39) | MAPK1KMT2AYEATS4NPC1RAB9A | |
| SCHEMBL2305706 | 0.77 | MAPK1 (0.39) | MAPK1KMT2AYEATS4NPC1RAB9A | |
| SCHEMBL20448715 | 0.77 | DAO (0.45) | — | |
| SCHEMBL11467474 | 0.74 | — | — | |
| SCHEMBL47581 | 0.74 | MAPK1 (0.45) | MAPK1KMT2AYEATS4NPC1RAB9A | |
| SCHEMBL2547124 | 0.69 | — | — | |
| SCHEMBL1522583 | 0.69 | MAPK1 (0.38) | MAPK1KMT2AYEATS4NPC1RAB9A | |
| SCHEMBL12632230 | 0.67 | GRM5 (0.39) | MAPK1KMT2A | |
| SCHEMBL12737778 | 0.67 | MAPK1 (0.41) | MAPK1KMT2AYEATS4NPC1RAB9A | |
| SCHEMBL498360 | 0.65 | MAPK1 (0.39) | MAPK1KMT2AYEATS4NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3310776-A2 | INHIBITORS OF BRUTON'S TYROSINE KINASE | Pharmacyclics LLC (US) | 2018-04-25 | — | — | EP | disclosed |
| WO-2016196776-A2 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS LLC. (US) | 2016-12-08 | — | — | WO | disclosed |
| EP-2393812-B1 | SUBSTITUTED SPIROAMIDES AS B1R-MODULATORS | GRUENENTHAL GMBH (DE) | 2013-07-03 | — | — | EP | disclosed |