Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 13/20 | 0.56 |
| ▸ | KDM1B | Q8NB78 | 6/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.56 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.42 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.32 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.32 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.32 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.32 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1506280 | 1.00 | KDM1A (0.56) | KDM1AKDM1BKCNH2RCOR1SLC9A1 | |
| SCHEMBL17780006 | 0.80 | KDM1A (0.58) | KDM1AKDM1BKCNH2RCOR1ABCC9 | |
| SCHEMBL15193017 | 0.80 | KDM1A (0.54) | KDM1AKDM1BKCNH2RCOR1SLC9A1 | |
| SCHEMBL30807092 | 0.80 | KDM1A (0.54) | KDM1AKDM1BKCNH2RCOR1SLC9A1 | |
| SCHEMBL21236290 | 0.79 | KDM1A (0.68) | KDM1AKDM1BKCNH2RCOR1SLC9A1 | |
| SCHEMBL20596701 | 0.77 | KDM1A (0.55) | KDM1AKDM1BKCNH2RCOR1ABCC9 | |
| SCHEMBL26991545 | 0.76 | KDM1A (0.53) | KDM1AKDM1BKCNH2RCOR1 | |
| SCHEMBL20269823 | 0.75 | MGLL (0.33) | KDM1AKDM1BKCNH2 | |
| SCHEMBL20269826 | 0.75 | MGLL (0.33) | KDM1AKDM1BKCNH2 | |
| SCHEMBL21314485 | 0.75 | MGLL (0.33) | KDM1AKDM1BKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888523-B1 | CYCLOBUTYL AMINE DERIVATIVES | ABBOTT LAB (US) | 2011-10-26 | — | — | EP | disclosed |
| EP-2298734-A2 | Cyclobutyl amine derivatives | Abbott Laboratories (US) | 2011-03-23 | — | — | EP | disclosed |
| US-20090227593-A1 | CYCLOBUTYL AMINE DERIVATIVES | ABBOTT LABORATORIES (US) | 2009-09-10 | — | — | US | disclosed |
| US-7553964-B2 | Cyclobutyl amine derivatives | ABBOTT LABORATORIES (US) | 2009-06-30 | — | — | US | disclosed |
| US-20070078133-A1 | Cyclobutyl amine derivatives | ABBVIE INC. | 2007-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227593-A1 | CYCLOBUTYL AMINE DERIVATIVES | HRH2, HRH4, HRH3 | KDM1A 3406/4885KDM1B 3503/4885KCNH2 1616/4885 |
| US-20070078133-A1 | Cyclobutyl amine derivatives | HRH2, HRH4, HRH3 | KDM1A 3406/4885KDM1B 3503/4885KCNH2 1616/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.