Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | XBP1 | P17861 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15063102 | 1.00 | GAA (0.45) | GAAPOLBSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL3971334 | 0.80 | POLB (0.43) | GAAPOLBSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL1581270 | 0.80 | POLB (0.43) | GAAPOLBSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL1581269 | 0.80 | POLB (0.43) | GAAPOLBSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL3576904 | 0.77 | GAA (0.56) | GAAPOLBSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL19961833 | 0.77 | GAA (0.56) | GAAPOLBSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL15524670 | 0.75 | POLB (0.41) | GAAPOLBSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL15524669 | 0.75 | POLB (0.41) | GAAPOLBSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL2296725 | 0.74 | POLB (0.58) | GAAPOLBSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL2296722 | 0.74 | POLB (0.58) | GAAPOLBSMN1; SMN2ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673339-B1 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC (US) | 2013-07-03 | — | — | EP | disclosed |