Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.42 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31208299 | 1.00 | POLB (0.58) | POLBSMN1; SMN2GAAALDH1A1CYP1A2 | |
| SCHEMBL2296722 | 1.00 | POLB (0.58) | POLBSMN1; SMN2GAAALDH1A1CYP1A2 | |
| SCHEMBL8752996 | 0.86 | POLB (0.56) | POLBSMN1; SMN2GAAALDH1A1CYP1A2 | |
| SCHEMBL19961833 | 0.85 | GAA (0.56) | POLBSMN1; SMN2GAAALDH1A1CYP1A2 | |
| SCHEMBL3576904 | 0.85 | GAA (0.56) | POLBSMN1; SMN2GAAALDH1A1CYP1A2 | |
| SCHEMBL529416 | 0.85 | POLB (0.70) | POLBSMN1; SMN2GAAALDH1A1CYP1A2 | |
| SCHEMBL26316343 | 0.82 | GAA (0.53) | POLBSMN1; SMN2GAAALDH1A1CYP1A2 | |
| SCHEMBL3978571 | 0.81 | POLB (0.55) | POLBSMN1; SMN2GAAALDH1A1CYP1A2 | |
| SCHEMBL21501547 | 0.81 | GAA (0.51) | POLBSMN1; SMN2GAAALDH1A1CYP1A2 | |
| SCHEMBL6526529 | 0.81 | POLB (0.61) | POLBSMN1; SMN2GAAALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240409533-A1 | HMOX1 INDUCERS | Astellas Engineered Small Molecules US, Incorporated | 2024-12-12 | — | — | US | disclosed |
| US-12071433-B2 | HMOX1 inducers | Astellas Engineered Small Molecules US, Incorporated (US) | 2024-08-27 | — | — | US | disclosed |
| US-20240051952-A1 | HMOX1 INDUCERS | Astellas Engineered Small Molecules US, Incorporated | 2024-02-15 | — | — | US | disclosed |
| US-20220177460-A1 | HMOX1 INDUCERS | Astellas Engineered Small Molecules US, Incorporated | 2022-06-09 | — | — | US | disclosed |
| US-20220177460-A1 | HMOX1 INDUCERS | Astellas Engineered Small Molecules US, Incorporated | 2022-06-09 | — | — | US | disclosed |
| EP-3952990-A1 | HMOX1 INDUCERS | Mitobridge, Inc. (US) | 2022-02-16 | — | — | EP | disclosed |
| CN-113874074-A | HMOX1 inducers | 米托布里奇公司 | 2021-12-31 | — | — | CN | disclosed |
| WO-2020210339-A1 | HMOX1 INDUCERS | MITOBRIDGE, INC. (US) | 2020-10-15 | — | — | WO | disclosed |
| WO-2020210339-A1 | HMOX1 INDUCERS | MITOBRIDGE, INC. (US) | 2020-10-15 | — | — | WO | disclosed |
| US-10766888-B1 | HMOX1 inducers | MITOBRIDGE INC. (US) | 2020-09-08 | — | — | US | disclosed |
| US-10766888-B1 | HMOX1 inducers | MITOBRIDGE INC. (US) | 2020-09-08 | — | — | US | disclosed |
| US-8841462-B2 | Bicyclic heterocycles as MEK kinase inhibitors | GENENTECH, INC. | 2014-09-23 | — | — | US | disclosed |
| US-20110190257-A1 | BICYCLIC HETEROCYCLES AS MEK KINASE INHIBITORS | GENETECH, INC. (US) | 2011-08-04 | — | — | US | disclosed |
| US-20110190257-A1 | BICYCLIC HETEROCYCLES AS MEK KINASE INHIBITORS | GENETECH, INC. (US) | 2011-08-04 | — | — | US | disclosed |
| US-20110190257-A1 | BICYCLIC HETEROCYCLES AS MEK KINASE INHIBITORS | GENETECH, INC. (US) | 2011-08-04 | — | — | US | disclosed |
| EP-1753428-A2 | KINASE INHIBITORS AS THERAPEUTIC AGENTS | Abbott Laboratories (US) | 2007-02-21 | — | — | EP | disclosed |
| US-20060074102-A1 | Kinase inhibitors as therapeutic agents | ABBOTT LABORATORIES | 2006-04-06 | — | — | US | disclosed |
| WO-2005110410-A2 | KINASE INHIBITORS AS THERAPEUTIC AGENTS | ABBOTT LABORATORIES (US) | 2005-11-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190257-A1 | BICYCLIC HETEROCYCLES AS MEK KINASE INHIBITORS | MAP2K7, MAP3K1, MAP3K5 | POLB 835/4885SMN1; SMN2 3917/4885GAA 4093/4885 |
| US-20060074102-A1 | Kinase inhibitors as therapeutic agents | ABL1, MAP3K19, MAP3K20 | POLB 2626/4885SMN1; SMN2 3776/4885GAA 1717/4885 |
| US-10766888-B1 | HMOX1 inducers | HMOX1, HMOX2, HMBS | POLB 3184/4885SMN1; SMN2 2893/4885GAA 2202/4885 |
| US-20240409533-A1 | HMOX1 INDUCERS | HMOX1, HMOX2, HMBS | POLB 3184/4885SMN1; SMN2 2893/4885GAA 2202/4885 |
| US-12071433-B2 | HMOX1 inducers | HMOX1, HMOX2, HMBS | POLB 2840/4885SMN1; SMN2 2872/4885GAA 2123/4885 |
| US-20240051952-A1 | HMOX1 INDUCERS | HMOX1, HMOX2, QSOX1 | POLB 3833/4885SMN1; SMN2 3190/4885GAA 1965/4885 |
| US-20220177460-A1 | HMOX1 INDUCERS | HMOX1, HMOX2, HMBS | POLB 2840/4885SMN1; SMN2 2872/4885GAA 2123/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.