Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPYD | Q12882 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | THPO | P40225 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HBB | P68871 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31090687 | 0.78 | DPYD (0.50) | DPYDALDH1A1MAPTLMNAGAA | |
| SCHEMBL327290 | 0.72 | DPYD (0.45) | DPYDALDH1A1MAPTLMNAGAA | |
| SCHEMBL1061623 | 0.71 | GAA (0.48) | DPYDALDH1A1MAPTLMNAGAA | |
| SCHEMBL5075425 | 0.69 | SLC22A6 (0.47) | DPYDALDH1A1MAPTLMNAGAA | |
| SCHEMBL6647291 | 0.69 | POLB (0.50) | DPYDALDH1A1MAPTLMNAGAA | |
| SCHEMBL1916526 | 0.69 | ATAD2 (0.47) | DPYDALDH1A1MAPTLMNAGAA | |
| SCHEMBL17991917 | 0.68 | GAA (0.45) | DPYDALDH1A1MAPTLMNAGAA | |
| SCHEMBL103605 | 0.67 | GAA (0.44) | DPYDALDH1A1MAPTLMNAGAA | |
| SCHEMBL29756976 | 0.67 | DPYD (0.43) | DPYD | |
| Formaldehyde SCHEMBL28861115 | 0.67 | POLB (0.48) | DPYDALDH1A1MAPTLMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2386556-B1 | Benzothiazole cyclobutyl amine derivatives and their use as histamine-3 receptors ligands | ABBVIE INC (US) | 2013-10-23 | — | — | EP | disclosed |
| EP-1926729-B1 | BENZOTHIAZOLE CYCLOBUTYL AMINE DERIVATIVES AND THEIR USE AS HISTAMINE-3 RECEPTORS LIGANDS | ABBOTT LAB (US) | 2011-12-21 | — | — | EP | disclosed |
| EP-2386556-A1 | Benzothiazole cyclobutyl amine derivatives and their use as histamine-3 receptors ligands | Abbott Laboratories (US) | 2011-11-16 | — | — | EP | disclosed |
| EP-1888523-B1 | CYCLOBUTYL AMINE DERIVATIVES | ABBOTT LAB (US) | 2011-10-26 | — | — | EP | disclosed |
| US-20110254413-A1 | CASING OF ELECTRONIC DEVICE AND MANUFACTURING METHOD THEREOF | ASUSTEK COMPUTER INC. (TW) | 2011-10-20 | — | — | US | disclosed |
| EP-2298734-A2 | Cyclobutyl amine derivatives | Abbott Laboratories (US) | 2011-03-23 | — | — | EP | disclosed |