Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 2/20 | 0.40 |
| ▸ | PDE1A | P54750 | 5/20 | 0.40 |
| ▸ | PDE1B | Q01064 | 5/20 | 0.40 |
| ▸ | PDE1C | Q14123 | 5/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.38 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.36 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.36 |
| ▸ | PRKDC | P78527 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | HCK | P08631 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15064660 | 0.82 | KDR (0.37) | MTORPDE1APDE1BPDE1CPIK3CD | |
| SCHEMBL15064773 | 0.81 | HDAC1 (0.37) | MTORPDE1APDE1BPDE1CPIK3CD | |
| SCHEMBL15064667 | 0.80 | FYN (0.37) | PDE1APDE1BPDE1CHSD17B1HSD17B2 | |
| SCHEMBL18561572 | 0.78 | KDR (0.47) | MTORPDE1APDE1BPDE1CPIK3CD | |
| SCHEMBL15064701 | 0.72 | PDE1A (0.39) | MTORPDE1APDE1BPDE1CPIK3CD | |
| SCHEMBL10094474 | 0.72 | HSD17B1 (0.42) | MTORPIK3CDHSD17B1HSD17B2CYP19A1 | |
| SCHEMBL13509089 | 0.69 | KDR (0.45) | MTORPIK3CDHSD17B1HSD17B2JAK2 | |
| SCHEMBL10094701 | 0.69 | CYP2A6 (0.57) | MTORPIK3CDHSD17B1HSD17B2CYP19A1 | |
| SCHEMBL569294 | 0.69 | PDE1A (0.39) | MTORPDE1APDE1BPDE1CPIK3CD | |
| SCHEMBL18868085 | 0.68 | SRC (0.72) | MTORPIK3CDPRKDCABL1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2601192-B1 | FUSED HETEROCYCLIC COMPOUNDS | TAKEDA PHARMACEUTICALS CO (JP) | 2017-03-01 | — | — | EP | disclosed |
| US-9029536-B2 | Fused heterocyclic compounds | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-05-12 | — | — | US | disclosed |
| US-20130172292-A1 | FUSED HETEROCYCLIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-07-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130172292-A1 | FUSED HETEROCYCLIC COMPOUNDS | PDE10A, PDE3A, PDE2A | MTOR 3598/4885PDE1A 15/4885PDE1B 14/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.