Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | FPR2 | P25090 | 7/20 | 0.49 |
| ▸ | FPR3 | P25089 | 3/20 | 0.49 |
| ▸ | IDO1 | P14902 | 2/20 | 0.48 |
| ▸ | TDO2 | P48775 | 1/20 | 0.48 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14731327 | 0.91 | KDM4E (0.69) | KDM4EPKMKMT2AFPR2FPR3 | |
| SCHEMBL12474430 | 0.90 | KDM4E (0.55) | KDM4EPKMKMT2AFPR2FPR3 | |
| SCHEMBL15064581 | 0.87 | KDM4E (0.49) | KDM4EPKMKMT2AFPR2FPR3 | |
| SCHEMBL16825871 | 0.84 | KDM4E (0.79) | KDM4EPKMKMT2AFPR2FPR3 | |
| SCHEMBL12474426 | 0.84 | HDAC3 (0.50) | KDM4EPKMHDAC1HDAC3HDAC2 | |
| SCHEMBL15064415 | 0.82 | HDAC3 (0.45) | KDM4EKMT2ANAMPTPOLBHDAC1 | |
| SCHEMBL15145007 | 0.82 | KDM4E (0.61) | KDM4EPKMKMT2AFPR2FPR3 | |
| SCHEMBL3448188 | 0.80 | KDM4E (0.69) | KDM4EPKMKMT2AACKR3NAMPT | |
| SCHEMBL3448190 | 0.80 | KDM4E (0.69) | KDM4EPKMKMT2AACKR3NAMPT | |
| SCHEMBL3448200 | 0.79 | KDM4E (0.67) | KDM4EPKMKMT2AACKR3GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130172384-A1 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED | 2013-07-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130172384-A1 | FATTY ACID SYNTHASE INHIBITORS | FASN, FADS1, FADS2 | KDM4E 2066/4885PKM 2131/4885KMT2A 2500/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.