Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 17/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 13/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 12/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 11/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.41 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.41 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.41 |
| ▸ | CSNK1G3 | Q9Y6M4 | 1/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15064464 | 0.90 | ADORA2B (0.43) | ADORA2BADORA2AADORA1ADORA3PLK4 | |
| SCHEMBL798904 | 0.89 | ADORA2B (0.43) | ADORA2BADORA2AADORA1ADORA3PLK4 | |
| SCHEMBL15064377 | 0.89 | ADORA2B (0.44) | ADORA2BADORA2AADORA1ADORA3PLK4 | |
| SCHEMBL15064437 | 0.88 | ADORA2B (0.44) | ADORA2BADORA2AADORA1ADORA3PLK4 | |
| SCHEMBL797623 | 0.88 | ADORA2B (0.42) | ADORA2BADORA2AADORA1ADORA3PLK4 | |
| SCHEMBL15064526 | 0.87 | ADORA2B (0.32) | ADORA2BADORA2AADORA1 | |
| SCHEMBL797684 | 0.86 | ADORA2B (0.43) | ADORA2BADORA2AADORA1ADORA3PLK4 | |
| SCHEMBL797627 | 0.86 | ADORA2B (0.43) | ADORA2BADORA2AADORA1ADORA3PLK4 | |
| SCHEMBL15064644 | 0.85 | ADORA2B (0.40) | ADORA2BADORA2AADORA1ADORA3PLK4 | |
| SCHEMBL15064359 | 0.82 | ADORA2B (0.46) | ADORA2BADORA2AADORA1ADORA3PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118001282-A | Pharmaceutical composition for cancer treatment | 因佩蒂斯生物科学有限公司 | 2024-05-10 | — | — | CN | claimed |
| EP-2616470-B1 | PURINE COMPOUNDS AS PRODRUGS OF A2B ADENOSINE RECEPTOR ANTAGONISTS, THEIR PROCESS AND MEDICINAL APPLICATIONS | ADVINUS THERAPEUTICS LTD (IN) | 2016-10-12 | — | — | EP | claimed |
| US-8940751-B2 | Purine compounds as prodrugs of A2B adenosine receptor antagonists, their process and medicinal applications | ADVINUS THERAPEUTICS PRIVATE LIMITED (IN) | 2015-01-27 | — | — | US | claimed |
| US-20130172249-A1 | PURINE COMPOUNDS AS PRODRUGS OF A2B ADENOSINE RECEPTOR ANTAGONISTS, THEIR PROCESS AND MEDICINAL APPLICATIONS | ADVINUS THERAPEUTICS PRIVATE LIMITED (IN) | 2013-07-04 | — | — | US | claimed |
| US-8940751-B2 | Purine compounds as prodrugs of A2B adenosine receptor antagonists, their process and medicinal applications | ADVINUS THERAPEUTICS PRIVATE LIMITED (IN) | 2015-01-27 | — | — | US | disclosed |
| US-20130172249-A1 | PURINE COMPOUNDS AS PRODRUGS OF A2B ADENOSINE RECEPTOR ANTAGONISTS, THEIR PROCESS AND MEDICINAL APPLICATIONS | ADVINUS THERAPEUTICS PRIVATE LIMITED (IN) | 2013-07-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130172249-A1 | PURINE COMPOUNDS AS PRODRUGS OF A2B ADENOSINE RECEPTOR ANTAGONISTS, THEIR PROCESS AND MEDICINAL APPLICATIONS | ADORA2B, ADORA2A, ADORA1 | ADORA2B 1/4885ADORA2A 2/4885ADORA1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.