Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.67 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.67 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | PTGER3 | P43115 | 4/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.48 |
| ▸ | PTGFR | P43088 | 2/20 | 0.48 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.48 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.48 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15065358 | 1.00 | HDAC8 (0.67) | HDAC8HDAC1HDAC6LMNAPTGER3 | |
| SCHEMBL15065280 | 0.85 | HDAC8 (0.67) | HDAC8HDAC1HDAC6LMNAPTGER3 | |
| SCHEMBL15065893 | 0.85 | HDAC8 (0.67) | HDAC8HDAC1HDAC6LMNAPTGER3 | |
| SCHEMBL15066373 | 0.85 | LMNA (0.74) | HDAC8HDAC1HDAC6LMNAPTGER3 | |
| SCHEMBL15066376 | 0.85 | LMNA (0.74) | HDAC8HDAC1HDAC6LMNAPTGER3 | |
| SCHEMBL15065737 | 0.82 | HTT (0.71) | HDAC8HDAC1HDAC6LMNAPTGER3 | |
| SCHEMBL15065736 | 0.82 | HTT (0.71) | HDAC8HDAC1HDAC6LMNAPTGER3 | |
| SCHEMBL15066105 | 0.81 | HDAC8 (0.61) | HDAC8HDAC1HDAC6LMNAPTGER3 | |
| SCHEMBL15066102 | 0.81 | HDAC8 (0.61) | HDAC8HDAC1HDAC6LMNAPTGER3 | |
| SCHEMBL15065894 | 0.80 | HDAC8 (0.60) | HDAC8HDAC1HDAC6LMNAPTGER3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150045367-A1 | CINNAMIC ACID HYDROXYAMIDES AS INHIBITORS OF HISTONE DEACETYLASE 8 | PHARMACYCLICS LLC | 2015-02-12 | — | — | US | claimed |
| EP-2797875-A1 | CINNAMIC ACID HYDROXYAMIDES AS INHIBITORS OF HISTONE DEACETYLASE 8 | Pharmacyclics, Inc. (US) | 2014-11-05 | — | — | EP | claimed |
| WO-2013101600-A1 | CINNAMIC ACID HYDROXYAMIDES AS INHIBITORS OF HISTONE DEACETYLASE 8 | PHARMACYCLICS, INC. (US) | 2013-07-04 | — | — | WO | claimed |
| US-20150045367-A1 | CINNAMIC ACID HYDROXYAMIDES AS INHIBITORS OF HISTONE DEACETYLASE 8 | PHARMACYCLICS LLC | 2015-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150045367-A1 | CINNAMIC ACID HYDROXYAMIDES AS INHIBITORS OF HISTONE DEACETYLASE 8 | HDAC8, HDAC5, HDAC7 | HDAC8 1/4885HDAC1 4/4885HDAC6 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.