Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.56 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.56 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 6/20 | 0.38 |
| ▸ | RAB9A | P51151 | 6/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16826535 | 0.83 | IRAK4 (0.37) | PIK3CDPIK3CBNPC1RAB9AMAPT | |
| SCHEMBL15086130 | 0.76 | PIK3CD (0.58) | PIK3CDPIK3CBALKNPC1RAB9A | |
| SCHEMBL22372346 | 0.75 | PIK3CD (0.62) | PIK3CDPIK3CBALKNPC1RAB9A | |
| SCHEMBL22372341 | 0.74 | PIK3CD (0.57) | PIK3CDPIK3CBALKNPC1RAB9A | |
| SCHEMBL30165793 | 0.74 | PIK3CD (0.57) | PIK3CDPIK3CBALKNPC1RAB9A | |
| SCHEMBL22372335 | 0.73 | PIK3CD (0.59) | PIK3CDPIK3CBALKNPC1RAB9A | |
| SCHEMBL21485987 | 0.73 | PIK3CD (0.54) | PIK3CDPIK3CBALKNPC1RAB9A | |
| SCHEMBL29524563 | 0.73 | PIK3CD (1.00) | PIK3CDPIK3CBALKNPC1RAB9A | |
| SCHEMBL592311 | 0.73 | PIK3CD (1.00) | PIK3CDPIK3CBALKNPC1RAB9A | |
| SCHEMBL29427470 | 0.73 | PIK3CD (1.00) | PIK3CDPIK3CBALKNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015095449-A1 | METHODS FOR MODULATING THE AMOUNT RNA TRANSCRIPTS | PTC THERAPEUTICS, INC. (US) | 2015-06-25 | — | — | WO | claimed |
| EP-2797592-A1 | COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY | PTC Therapeutics, Inc. (US) | 2014-11-05 | — | — | EP | claimed |
| WO-2013101974-A1 | COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY | PTC THERAPEUTICS, INC. (US) | 2013-07-04 | — | — | WO | claimed |
| WO-2015095449-A1 | METHODS FOR MODULATING THE AMOUNT RNA TRANSCRIPTS | PTC THERAPEUTICS, INC. (US) | 2015-06-25 | — | — | WO | disclosed |