SCHEMBL22372341

SCHEMBL22372341

O=C(O)C1CCN(c2ccc3cc(-c4nc5ccccc5s4)c(=O)oc3c2)C1

nearest known ligand 0.57

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ PIK3CD O00329 1/20 0.57
▸ PIK3CB P42338 1/20 0.57
▸ ALK Q9UM73 2/20 0.51
▸ NOTUM Q6P988 13/20 0.43
▸ NPC1 O15118 1/20 0.39
▸ RAB9A P51151 1/20 0.39
▸ S1PR1 P21453 1/20 0.38
▸ SLC16A3 O15427 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30165793 1.00 PIK3CD (0.57) PIK3CDPIK3CBALKNOTUMNPC1
SCHEMBL22372335 0.95 PIK3CD (0.59) PIK3CDPIK3CBALKNPC1RAB9A
SCHEMBL22372346 0.94 PIK3CD (0.62) PIK3CDPIK3CBALKNPC1RAB9A
SCHEMBL25997260 0.86 PIK3CD (0.58) PIK3CDPIK3CBALKNPC1RAB9A
SCHEMBL25997259 0.84 PIK3CD (0.60) PIK3CDPIK3CBALKNPC1RAB9A
SCHEMBL25997262 0.82 PIK3CD (0.62) PIK3CDPIK3CBALKNPC1RAB9A
SCHEMBL16674768 0.82 PIK3CD (0.64) PIK3CDPIK3CBALKNPC1RAB9A
SCHEMBL22372330 0.81 ALK (0.54) PIK3CDPIK3CBALKNPC1S1PR1
SCHEMBL4505188 0.81 PIK3CD (0.63) PIK3CDPIK3CBALKNPC1RAB9A
SCHEMBL4505982 0.80 PIK3CD (0.62) PIK3CDPIK3CBALKNPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12031178-B2 Cyclooctatetraene containing dyes and compositions ILLUMINA CAMBRIDGE LIMITED (GB) 2024-07-09 — — US disclosed
US-11884825-B2 Exocyclic amine substituted coumarin compounds and uses as fluorescent labels ILLUMINA CAMBRIDGE LIMITED (GB) 2024-01-30 — — US disclosed
US-20230265503-A1 CYCLOOCTATETRAENE CONTAINING DYES AND COMPOSITIONS ILLUMINA CAMBRIDGE LIMITED (GB) 2023-08-24 — — US disclosed
US-20230265502-A1 CYCLOOCTATETRAENE CONTAINING DYES AND COMPOSITIONS ILLUMINA CAMBRIDGE LIMITED (GB) 2023-08-24 — — US disclosed
US-20230022437-A1 EXOCYCLIC AMINE SUBSTITUTED COUMARIN COMPOUNDS AND USES AS FLUORESCENT LABELS ILLUMINA CAMBRIDGE LIMITED (GB) 2023-01-26 — — US disclosed
US-20230022437-A1 EXOCYCLIC AMINE SUBSTITUTED COUMARIN COMPOUNDS AND USES AS FLUORESCENT LABELS ILLUMINA CAMBRIDGE LIMITED (GB) 2023-01-26 — — US disclosed
US-11390753-B2 Exocyclic amine substituted coumarin compounds and uses as fluorescent labels ILLUMINA CAMBRIDGE LIMITED (GB) 2022-07-19 — — US disclosed
WO-2022136402-A1 METHODS AND COMPOSITIONS FOR NUCLEIC ACID SEQUENCING ILLUMINA CAMBRIDGE LIMITED (GB) 2022-06-30 — — WO disclosed
US-20220195518-A1 METHODS AND COMPOSITIONS FOR NUCLEIC ACID SEQUENCING ILLUMINA CAMBRIDGE LIMITED (GB) 2022-06-23 — — US disclosed
US-20220049292-A1 MULTIPLEXED FLUORESCENT DETECTION OF ANALYTES ILLUMINA CAMBRIDGE LIMITED (GB) 2022-02-17 — — US disclosed
US-20220049292-A1 MULTIPLEXED FLUORESCENT DETECTION OF ANALYTES ILLUMINA CAMBRIDGE LIMITED (GB) 2022-02-17 — — US disclosed
EP-3931263-A1 EXOCYCLIC AMINE SUBSTITUTED COUMARIN COMPOUNDS AND THEIR USES AS FLUORESCENT LABELS Illumina Cambridge Limited (GB) 2022-01-05 — — EP disclosed
EP-3837384-A1 MULTIPLEXED FLUORESCENT DETECTION OF ANALYTES Illumina, Inc. (US) 2021-06-23 — — EP disclosed
CN-112969802-A Multiplex fluorescence detection of analytes 伊鲁米那股份有限公司 2021-06-15 — — CN disclosed
WO-2021104845-A1 CYCLOOCTATETRAENE CONTAINING DYES AND COMPOSITIONS ILLUMINA CAMBRIDGE LIMITED (GB) 2021-06-03 — — WO disclosed
US-20210155983-A1 CYCLOOCTATETRAENE CONTAINING DYES AND COMPOSITIONS ILLUMINA CAMBRIDGE LIMITED (GB) 2021-05-27 — — US disclosed
CN-112654681-A Exocyclic amine substituted coumarin compound and application thereof as fluorescent marker 伊卢米纳剑桥有限公司 2021-04-13 — — CN disclosed
US-20200277529-A1 EXOCYCLIC AMINE SUBSTITUTED COUMARIN COMPOUNDS AND USES AS FLUORESCENT LABELS ILLUMINA CAMBRIDGE LIMITED (GB) 2020-09-03 — — US disclosed
US-20200277529-A1 EXOCYCLIC AMINE SUBSTITUTED COUMARIN COMPOUNDS AND USES AS FLUORESCENT LABELS ILLUMINA CAMBRIDGE LIMITED (GB) 2020-09-03 — — US disclosed
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