Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 18/20 | 0.40 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.40 |
| ▸ | TNKS | O95271 | 1/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.40 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15067691 | 0.97 | PARP1 (0.40) | PARP1PARP2TNKSTNKS2PARP3 | |
| SCHEMBL15084448 | 0.96 | PARP1 (0.39) | PARP1PARP2TNKSTNKS2PARP3 | |
| Hydrochloric Acid SCHEMBL17704119 | 0.82 | PARP1 (0.40) | PARP1PARP2TNKSTNKS2PARP3 | |
| SCHEMBL15069522 | 0.81 | PARP1 (0.39) | PARP1PARP2TNKSTNKS2PARP3 | |
| SCHEMBL18686101 | 0.80 | PARP1 (0.47) | PARP1PARP2TNKSTNKS2PARP3 | |
| SCHEMBL24317868 | 0.76 | ATM (0.47) | PARP1PARP2TNKSTNKS2PARP3 | |
| SCHEMBL30530525 | 0.76 | ATM (0.47) | PARP1PARP2TNKSTNKS2PARP3 | |
| SCHEMBL15084461 | 0.76 | PARP1 (0.43) | PARP1PARP2TNKSTNKS2PARP3 | |
| SCHEMBL15084477 | 0.75 | CREBBP (0.38) | PARP1KMT2A | |
| SCHEMBL15084459 | 0.75 | PARP1 (0.57) | PARP1PARP2TNKSTNKS2PARP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2797919-B1 | FUSED TETRA OR PENTA-CYCLIC PYRIDOPHTHALAZINONES AS PARP INHIBITORS | BEIGENE LTD (KY) | 2017-03-29 | — | — | EP | disclosed |
| EP-2797919-B1 | FUSED TETRA OR PENTA-CYCLIC PYRIDOPHTHALAZINONES AS PARP INHIBITORS | BEIGENE LTD (KY) | 2017-03-29 | — | — | EP | disclosed |
| US-9328111-B2 | Substituted cycloocta[5,6]pyrido[4,3,2-de]phthalazines as PARP inhibitors | BEIGENE LTD. (KY) | 2016-05-03 | — | — | US | disclosed |
| US-9328111-B2 | Substituted cycloocta[5,6]pyrido[4,3,2-de]phthalazines as PARP inhibitors | BEIGENE LTD. (KY) | 2016-05-03 | — | — | US | disclosed |
| EP-2797919-A1 | FUSED TETRA OR PENTA-CYCLIC PYRIDOPHTHALAZINONES AS PARP INHIBITORS | BeiGene, Ltd. (KY) | 2014-11-05 | — | — | EP | disclosed |
| WO-2013097226-A1 | FUSED TETRA OR PENTA-CYCLIC PYRIDOPHTHALAZINONES AS PARP INHIBITORS | BEIGENE, LTD. (KY) | 2013-07-04 | — | — | WO | disclosed |
| WO-2013097226-A1 | FUSED TETRA OR PENTA-CYCLIC PYRIDOPHTHALAZINONES AS PARP INHIBITORS | BEIGENE, LTD. (KY) | 2013-07-04 | — | — | WO | disclosed |