Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 18/20 | 0.57 |
| ▸ | PARP2 | Q9UGN5 | 4/20 | 0.46 |
| ▸ | PARP3 | Q9Y6F1 | 3/20 | 0.46 |
| ▸ | TNKS | O95271 | 1/20 | 0.45 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18686101 | 0.81 | PARP1 (0.47) | PARP1PARP2PARP3TNKSTNKS2 | |
| SCHEMBL17704120 | 0.76 | PARP1 (0.41) | PARP1PARP2PARP3TNKSTNKS2 | |
| SCHEMBL15068064 | 0.75 | PARP1 (0.40) | PARP1PARP2PARP3TNKSTNKS2 | |
| SCHEMBL15067691 | 0.75 | PARP1 (0.40) | PARP1PARP2PARP3TNKSTNKS2 | |
| SCHEMBL15084450 | 0.74 | PARP1 (0.39) | PARP1PARP2PARP3TNKSTNKS2 | |
| SCHEMBL15084448 | 0.74 | PARP1 (0.39) | PARP1PARP2PARP3TNKSTNKS2 | |
| SCHEMBL15084458 | 0.74 | PARP1 (0.44) | PARP1PARP2TNKSTNKS2ROCK2 | |
| SCHEMBL15084457 | 0.74 | PARP1 (0.52) | PARP1PARP2TNKSTNKS2ROCK2 | |
| SCHEMBL15084462 | 0.73 | PARP1 (0.44) | PARP1PARP2TNKSTNKS2ROCK2 | |
| SCHEMBL15069702 | 0.73 | PARP1 (0.52) | PARP1PARP2TNKSTNKS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2797919-B1 | FUSED TETRA OR PENTA-CYCLIC PYRIDOPHTHALAZINONES AS PARP INHIBITORS | BEIGENE LTD (KY) | 2017-03-29 | — | — | EP | disclosed |
| EP-2797919-B1 | FUSED TETRA OR PENTA-CYCLIC PYRIDOPHTHALAZINONES AS PARP INHIBITORS | BEIGENE LTD (KY) | 2017-03-29 | — | — | EP | disclosed |
| US-9328111-B2 | Substituted cycloocta[5,6]pyrido[4,3,2-de]phthalazines as PARP inhibitors | BEIGENE LTD. (KY) | 2016-05-03 | — | — | US | disclosed |
| US-9328111-B2 | Substituted cycloocta[5,6]pyrido[4,3,2-de]phthalazines as PARP inhibitors | BEIGENE LTD. (KY) | 2016-05-03 | — | — | US | disclosed |
| WO-2013097226-A1 | FUSED TETRA OR PENTA-CYCLIC PYRIDOPHTHALAZINONES AS PARP INHIBITORS | BEIGENE, LTD. (KY) | 2013-07-04 | — | — | WO | disclosed |