Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | NCF1 | P14598 | 1/20 | 0.39 |
| ▸ | C1R | P00736 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16669959 | 0.94 | C1R (0.43) | ALDH1A1KDM4EMAPTNPC1HPGD | |
| Hydrochloric Acid SCHEMBL15068709 | 0.93 | C1R (0.42) | ALDH1A1KDM4EMAPTNPC1HPGD | |
| SCHEMBL15086397 | 0.93 | HRH4 (0.43) | ALDH1A1KDM4EMAPTNPC1HPGD | |
| Hydrochloric Acid SCHEMBL15069015 | 0.92 | HRH4 (0.42) | ALDH1A1KDM4EMAPTNPC1HPGD | |
| Trifluoroacetic Acid SCHEMBL15068525 | 0.89 | C1R (0.41) | ALDH1A1KDM4EMAPTNPC1HPGD | |
| Trifluoroacetic Acid SCHEMBL15068701 | 0.88 | BACE1 (0.42) | ALDH1A1HRH4NCF1JAK2JAK1 | |
| SCHEMBL15069087 | 0.81 | MAPT (0.40) | ALDH1A1KDM4EMAPTNPC1HPGD | |
| SCHEMBL15068964 | 0.81 | HTR7 (0.41) | ALDH1A1KDM4EMAPTNPC1HPGD | |
| Hydrochloric Acid SCHEMBL15069757 | 0.80 | MAPT (0.40) | ALDH1A1KDM4EMAPTNPC1HPGD | |
| Hydrochloric Acid SCHEMBL15066908 | 0.80 | HTR7 (0.41) | ALDH1A1KDM4EMAPTNPC1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2797592-A1 | COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY | PTC Therapeutics, Inc. (US) | 2014-11-05 | — | — | EP | claimed |
| WO-2013101974-A1 | COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY | PTC THERAPEUTICS, INC. (US) | 2013-07-04 | — | — | WO | claimed |