Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.64 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.57 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | IKBKB | O14920 | 3/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15063693 | 0.86 | KDR (0.61) | KDRPDGFRBGAAMEN1KMT2A | |
| SCHEMBL15063859 | 0.83 | KDR (0.70) | KDRPDGFRBMEN1IKBKBBRAF | |
| SCHEMBL18955834 | 0.83 | KDR (0.58) | KDRPDGFRBMEN1KMT2AIKBKB | |
| SCHEMBL14697805 | 0.83 | KDR (0.58) | KDRPDGFRBGAAMEN1KMT2A | |
| SCHEMBL15063770 | 0.81 | KDR (0.73) | KDRPDGFRBGAAMEN1KMT2A | |
| SCHEMBL15063739 | 0.79 | KDR (1.00) | KDRPDGFRBIKBKBBRAFCYP1A2 | |
| SCHEMBL15063946 | 0.78 | KDR (0.53) | KDRPDGFRBGAAMEN1KMT2A | |
| SCHEMBL22593541 | 0.78 | KDR (0.78) | KDRPDGFRBIKBKBBRAFCDK5 | |
| SCHEMBL18513466 | 0.78 | KDR (0.62) | KDRPDGFRBGAAMEN1KMT2A | |
| SCHEMBL10429363 | 0.77 | MEN1 (0.50) | KDRGAAMEN1KMT2AIKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3184525-A1 | 3-PHENYL-5-UREIDOISOTHIAZOLE-4-CABOXIMIDE AND 3-AMINO-5-PHENYLISOTHIAZOLE DERIVATIVES AS KINASE INHIBITORS | ALLERGAN, INC. (US) | 2017-06-28 | — | — | EP | disclosed |
| US-8969583-B2 | 3-phenyl-5-ureidoisothiazole-4-carboximide and 3-amino-5-phenylisothiazole derivatives as kinase inhibitors | ALLERGAN, INC. (US) | 2015-03-03 | — | — | US | disclosed |
| US-20130172353-A1 | 3-PHENYL-5-UREIDOISOTHIAZOLE-4-CARBOXIMIDE AND 3-AMINO-5-PHENYLISOTHIAZOLE DERIVATIVES AS KINASE INHIBITORS | ALLERGAN, INC. (US) | 2013-07-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130172353-A1 | 3-PHENYL-5-UREIDOISOTHIAZOLE-4-CARBOXIMIDE AND 3-AMINO-5-PHENYLISOTHIAZOLE DERIVATIVES AS KINASE INHIBITORS | REN, JAK2, FGFR1 | KDR 30/4885PDGFRB 12/4885GAA 2745/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.