Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIP4K2A | P48426 | 9/20 | 0.44 |
| ▸ | BRAF | P15056 | 3/20 | 0.42 |
| ▸ | CSF1R | P07333 | 2/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.42 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 2/20 | 0.41 |
| ▸ | TEK | Q02763 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | TNF | P01375 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15069754 | 0.86 | BRAF (0.55) | BRAFCSF1RRAF1DDR1DDR2 | |
| SCHEMBL15069728 | 0.86 | BRAF (0.42) | BRAFCSF1RRAF1DDR1DDR2 | |
| SCHEMBL15068707 | 0.83 | BRAF (0.55) | BRAFCSF1RRAF1DDR1DDR2 | |
| SCHEMBL15069738 | 0.82 | BRAF (0.45) | BRAFCSF1RRAF1DDR1DDR2 | |
| SCHEMBL15069205 | 0.81 | BRAF (0.44) | BRAFCSF1RRAF1DDR1DDR2 | |
| SCHEMBL15066146 | 0.81 | PIK3CG (0.41) | PIP4K2ABRAFCSF1RRAF1DDR1 | |
| SCHEMBL15069808 | 0.81 | BRAF (0.43) | BRAFCSF1RRAF1DDR1DDR2 | |
| SCHEMBL26373434 | 0.79 | PIP4K2A (0.50) | PIP4K2AMAPTGRM4LMNATP53 | |
| SCHEMBL15069790 | 0.79 | BRAF (0.43) | BRAFCSF1RRAF1DDR1DDR2 | |
| SCHEMBL15069219 | 0.79 | BRAF (0.44) | BRAFCSF1RRAF1DDR1DDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2797927-A1 | THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES | Hanmi Pharm. Co., Ltd. (KR) | 2014-11-05 | — | — | EP | disclosed |
| WO-2013100632-A1 | THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES | HANMI PHARM CO., LTD. (KR) | 2013-07-04 | — | — | WO | disclosed |