Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 15/20 | 0.45 |
| ▸ | LCK | P06239 | 8/20 | 0.45 |
| ▸ | TEK | Q02763 | 7/20 | 0.45 |
| ▸ | KDR | P35968 | 5/20 | 0.45 |
| ▸ | RAF1 | P04049 | 7/20 | 0.43 |
| ▸ | CSF1R | P07333 | 4/20 | 0.43 |
| ▸ | DDR1 | Q08345 | 4/20 | 0.43 |
| ▸ | DDR2 | Q16832 | 4/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.37 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.37 |
| ▸ | TNF | P01375 | 2/20 | 0.34 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.34 |
| ▸ | FADS1 | O60427 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15069728 | 0.90 | BRAF (0.42) | BRAFLCKTEKKDRRAF1 | |
| SCHEMBL15068707 | 0.90 | BRAF (0.55) | BRAFLCKTEKKDRRAF1 | |
| SCHEMBL15069754 | 0.86 | BRAF (0.55) | BRAFLCKTEKKDRRAF1 | |
| SCHEMBL15069219 | 0.85 | BRAF (0.44) | BRAFLCKTEKKDRRAF1 | |
| SCHEMBL15069205 | 0.85 | BRAF (0.44) | BRAFLCKTEKKDRRAF1 | |
| SCHEMBL15069808 | 0.84 | BRAF (0.43) | BRAFLCKTEKKDRRAF1 | |
| SCHEMBL15069866 | 0.84 | BRAF (0.42) | BRAFLCKTEKKDRRAF1 | |
| SCHEMBL15069818 | 0.83 | BRAF (0.46) | BRAFLCKTEKKDRRAF1 | |
| SCHEMBL15069790 | 0.83 | BRAF (0.43) | BRAFLCKTEKKDRRAF1 | |
| SCHEMBL15069746 | 0.82 | PIP4K2A (0.44) | BRAFLCKTEKKDRRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2797927-A1 | THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES | Hanmi Pharm. Co., Ltd. (KR) | 2014-11-05 | — | — | EP | disclosed |
| WO-2013100632-A1 | THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES | HANMI PHARM CO., LTD. (KR) | 2013-07-04 | — | — | WO | disclosed |