Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 15/20 | 0.55 |
| ▸ | RAF1 | P04049 | 7/20 | 0.55 |
| ▸ | LCK | P06239 | 8/20 | 0.39 |
| ▸ | TEK | Q02763 | 7/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 5/20 | 0.38 |
| ▸ | CSF1R | P07333 | 4/20 | 0.37 |
| ▸ | DDR1 | Q08345 | 4/20 | 0.37 |
| ▸ | DDR2 | Q16832 | 4/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.32 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.32 |
| ▸ | BCDIN3D | Q7Z5W3 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15069773 | 0.91 | BRAF (0.46) | BRAFRAF1LCKTEKKDR | |
| SCHEMBL15069790 | 0.85 | BRAF (0.43) | BRAFRAF1LCKTEKKDR | |
| SCHEMBL15069205 | 0.85 | BRAF (0.44) | BRAFRAF1LCKTEKKDR | |
| SCHEMBL15068707 | 0.83 | BRAF (0.55) | BRAFRAF1LCKTEKKDR | |
| SCHEMBL15069219 | 0.82 | BRAF (0.44) | BRAFRAF1LCKTEKROCK1 | |
| SCHEMBL15067507 | 0.80 | BRAF (0.55) | BRAFRAF1LCKTEKKDR | |
| SCHEMBL15067429 | 0.79 | BRAF (0.56) | BRAFRAF1LCKTEKKDR | |
| SCHEMBL15066146 | 0.78 | PIK3CG (0.41) | BRAFRAF1LCKTEKKDR | |
| SCHEMBL27985938 | 0.78 | BRAF (0.42) | BRAFRAF1LCKTEKKDR | |
| SCHEMBL15069808 | 0.78 | BRAF (0.43) | BRAFRAF1LCKTEKKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2797927-A1 | THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES | Hanmi Pharm. Co., Ltd. (KR) | 2014-11-05 | — | — | EP | disclosed |
| WO-2013100632-A1 | THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES | HANMI PHARM CO., LTD. (KR) | 2013-07-04 | — | — | WO | disclosed |