Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 12/20 | 0.42 |
| ▸ | LCK | P06239 | 5/20 | 0.42 |
| ▸ | TEK | Q02763 | 4/20 | 0.42 |
| ▸ | KDR | P35968 | 4/20 | 0.42 |
| ▸ | RAF1 | P04049 | 7/20 | 0.41 |
| ▸ | CSF1R | P07333 | 4/20 | 0.41 |
| ▸ | DDR1 | Q08345 | 4/20 | 0.41 |
| ▸ | DDR2 | Q16832 | 4/20 | 0.41 |
| ▸ | ARAF | P10398 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 2/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15069753 | 0.87 | BRAF (0.46) | BRAFLCKTEKKDRRAF1 | |
| SCHEMBL15069754 | 0.86 | BRAF (0.55) | BRAFLCKTEKKDRRAF1 | |
| SCHEMBL15068707 | 0.85 | BRAF (0.55) | BRAFLCKTEKKDRRAF1 | |
| SCHEMBL15069738 | 0.84 | BRAF (0.45) | BRAFLCKTEKKDRRAF1 | |
| SCHEMBL15068847 | 0.83 | BRAF (0.54) | BRAFLCKTEKKDRRAF1 | |
| SCHEMBL15069728 | 0.81 | BRAF (0.42) | BRAFLCKTEKKDRRAF1 | |
| SCHEMBL15069818 | 0.81 | BRAF (0.46) | BRAFLCKTEKKDRRAF1 | |
| SCHEMBL15069790 | 0.81 | BRAF (0.43) | BRAFLCKTEKKDRRAF1 | |
| SCHEMBL15065889 | 0.78 | BRAF (0.42) | BRAFLCKTEKKDRRAF1 | |
| SCHEMBL15069219 | 0.78 | BRAF (0.44) | BRAFLCKTEKKDRRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2797927-A1 | THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES | Hanmi Pharm. Co., Ltd. (KR) | 2014-11-05 | — | — | EP | disclosed |
| WO-2013100632-A1 | THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES | HANMI PHARM CO., LTD. (KR) | 2013-07-04 | — | — | WO | disclosed |