Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | ENPP3 | O14638 | 2/20 | 0.40 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.40 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29664915 | 1.00 | CYP2D6 (0.53) | CYP2D6CYP1A2ACHECYP3A4CYP2C19 | |
| SCHEMBL26906382 | 1.00 | CYP2D6 (0.53) | CYP2D6CYP1A2ACHECYP3A4CYP2C19 | |
| SCHEMBL11170553 | 0.91 | CYP2D6 (0.59) | CYP2D6CYP1A2ACHECYP3A4CYP2C19 | |
| SCHEMBL11170559 | 0.91 | CYP2D6 (0.59) | CYP2D6CYP1A2ACHECYP3A4CYP2C19 | |
| SCHEMBL2863064 | 0.91 | CYP2D6 (0.56) | CYP2D6CYP1A2ACHECYP3A4CYP2C19 | |
| SCHEMBL4318482 | 0.89 | CYP2D6 (0.56) | CYP2D6CYP1A2ACHECYP3A4CYP2C19 | |
| SCHEMBL20203253 | 0.86 | CYP2D6 (0.56) | CYP2D6CYP1A2CYP3A4CYP2C19ENPP3 | |
| SCHEMBL11027801 | 0.86 | CYP2D6 (0.56) | CYP2D6CYP1A2CYP3A4CYP2C19ENPP3 | |
| SCHEMBL11027802 | 0.86 | CYP2D6 (0.56) | CYP2D6CYP1A2CYP3A4CYP2C19ENPP3 | |
| SCHEMBL6198029 | 0.86 | CYP2D6 (0.63) | CYP2D6CYP1A2ACHECYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12435079-B2 | Bruton's tyrosine kinase inhibitors | Liao, Xibin (US) | 2025-10-07 | — | — | US | disclosed |
| WO-2025011533-A1 | CARBOXYLIC ACID COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 上海宇道生物技术有限公司 | 2025-01-16 | — | — | WO | disclosed |
| CN-118955505-A | Bruton tyrosine kinase inhibitors | 杭州邦顺制药有限公司 | 2024-11-15 | — | — | CN | disclosed |
| CN-118955506-A | Bruton tyrosine kinase inhibitors | 杭州邦顺制药有限公司 | 2024-11-15 | — | — | CN | disclosed |
| CN-113365631-B | Bruton tyrosine kinase inhibitors | 杭州邦顺制药有限公司 | 2024-08-30 | — | — | CN | disclosed |
| US-20240158392-A1 | SMALL MOLECULE INHIBITORS OF SALT INDUCIBLE KINASES | JANSSEN RESEARCH & DEVELOPMENT, LLC | 2024-05-16 | — | — | US | disclosed |
| EP-4284801-A1 | SMALL MOLECULE INHIBITORS OF SALT INDUCIBLE KINASES | Janssen Biotech, Inc. (US) | 2023-12-06 | — | — | EP | disclosed |
| CN-116583285-A | N- (imidazo [1,2-b ] pyridazin-3-yl) -1-cyclohexyl-2H-indazole-5-carboxamide and N- (pyrazolo [1,5-a ] pyrimidin-3-yl) -1-cyclohexyl-2H-indazole-5-carboxamide derivatives as IRAK4 inhibitors for the treatment of asthma | 阿斯利康(瑞典)有限公司 | 2023-08-11 | — | — | CN | disclosed |
| WO-2022165529-A1 | SMALL MOLECULE INHIBITORS OF SALT INDUCIBLE KINASES | JANSSEN BIOTECH, INC. (US) | 2022-08-04 | — | — | WO | disclosed |
| US-20220064162-A1 | BRUTON'S TYROSINE KINASE INHIBITORS | LIAO, XIBIN | 2022-03-03 | — | — | US | disclosed |
| CN-113365631-A | Bruton's tyrosine kinase inhibitors | 杭州邦顺制药有限公司 | 2021-09-07 | — | — | CN | disclosed |
| US-9162223-B2 | Alkaline-stable chromatographic resins | NORTH CAROLINA STATE UNIVERSITY (US) | 2015-10-20 | — | — | US | disclosed |
| US-20130165539-A1 | ALKALINE-STABLE CHROMATOGRAPHIC RESINS | NORTH CAROLINA STATE UNIVERSITY (US) | 2013-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12435079-B2 | Bruton's tyrosine kinase inhibitors | BTK, ABL1, SYK | CYP2D6 2008/4885CYP1A2 2413/4885ACHE 4469/4885 |
| US-20240158392-A1 | SMALL MOLECULE INHIBITORS OF SALT INDUCIBLE KINASES | SIK2, SIK1, SGK2 | CYP2D6 4759/4885CYP1A2 4537/4885ACHE 4813/4885 |
| US-20220064162-A1 | BRUTON'S TYROSINE KINASE INHIBITORS | BTK, ABL1, SYK | CYP2D6 2008/4885CYP1A2 2413/4885ACHE 4469/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.