Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 2/20 | 0.36 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | IDH1 | O75874 | 4/20 | 0.32 |
| ▸ | ELOVL1 | Q9BW60 | 2/20 | 0.31 |
| ▸ | PLK1 | P53350 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | SYK | P43405 | 1/20 | 0.30 |
| ▸ | ATP1A1 | P05023 | 1/20 | 0.30 |
| ▸ | ATP1B1 | P05026 | 1/20 | 0.30 |
| ▸ | ATP1A3 | P13637 | 1/20 | 0.30 |
| ▸ | ATP1B2 | P14415 | 1/20 | 0.30 |
| ▸ | ATP1A2 | P50993 | 1/20 | 0.30 |
| ▸ | ATP1B3 | P54709 | 1/20 | 0.30 |
| ▸ | FXYD2 | P54710 | 1/20 | 0.30 |
| ▸ | ATP1A4 | Q13733 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4094681 | 0.85 | MAPK14 (0.36) | MAP3K12IDH1PLK1 | |
| SCHEMBL13708552 | 0.70 | MAPK14 (0.43) | MAP3K12 | |
| SCHEMBL4092452 | 0.70 | MAPK14 (0.43) | MAP3K12 | |
| SCHEMBL19368143 | 0.69 | MAP3K12 (0.39) | MAP3K12GAACHRNA7KCNH2SYK | |
| SCHEMBL4084908 | 0.67 | PLK1 (0.42) | IDH1PLK1 | |
| SCHEMBL4094807 | 0.67 | PLK1 (0.42) | IDH1PLK1 | |
| SCHEMBL4094651 | 0.67 | PLK1 (0.42) | IDH1PLK1 | |
| SCHEMBL15072210 | 0.67 | CHRNB2 (0.45) | — | |
| SCHEMBL4094679 | 0.65 | PLK1 (0.48) | PLK1 | |
| SCHEMBL4096056 | 0.65 | PLK1 (0.41) | PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130165464-A1 | HETEROARYLS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130165464-A1 | HETEROARYLS AND USES THEREOF | PIK3C2B, PI4KB, PIK3R4 | CASR 4238/4885MAP3K12 1518/4885BRD4 253/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.