Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.47 |
| ▸ | MAPK7 | Q13164 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10042102 | 0.80 | MAPK14 (0.52) | L3MBTL1MAPK14MAPK7HTT | |
| SCHEMBL299630 | 0.72 | POLB (0.50) | ALDH1A1MAPK14MAPK7LMNA | |
| SCHEMBL297517 | 0.71 | MAPK14 (0.47) | ALDH1A1MAPK14MAPK7HTTLMNA | |
| SCHEMBL10042100 | 0.70 | POLB (0.49) | ALDH1A1MAPK14MAPK7HTTLMNA | |
| SCHEMBL298823 | 0.70 | MAPK14 (0.46) | ALDH1A1CYP1A2CYP2C19MAPK14MAPK7 | |
| SCHEMBL606462 | 0.70 | MAPK14 (0.46) | ALDH1A1CYP1A2CYP2C19MAPK14MAPK7 | |
| SCHEMBL298824 | 0.70 | BAZ2B (0.55) | ALDH1A1MAPK14MAPK7HTTLMNA | |
| SCHEMBL10042044 | 0.70 | MAPK14 (0.50) | L3MBTL1HPGDALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL13074869 | 0.69 | MAPK14 (0.44) | L3MBTL1MAPK14MAPK7HTT | |
| SCHEMBL13074868 | 0.68 | HTT (0.49) | HPGDALDH1A1CYP1A2CYP2C19MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300485-A1 | PYRROLO Ý2, 3-C¨PYRIDINE DERIVATIVES AS P38 KINASE INHIBITING AGENTS | Merck Sharp & Dohme Corp. (US) | 2011-03-30 | — | — | EP | disclosed |