Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 18/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 15/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15073326 | 0.91 | DGAT1 (0.58) | DGAT1KCNH2CYP2C9CYP3A4FFAR4 | |
| SCHEMBL15073176 | 0.91 | DGAT1 (0.59) | DGAT1KCNH2CYP2C9CYP3A4FFAR4 | |
| SCHEMBL15073357 | 0.87 | DGAT1 (0.55) | DGAT1KCNH2CYP2C9CYP3A4FFAR4 | |
| SCHEMBL15073175 | 0.86 | DGAT1 (0.58) | DGAT1KCNH2CYP2C9CYP3A4FFAR4 | |
| SCHEMBL15073361 | 0.86 | DGAT1 (0.54) | DGAT1KCNH2CYP2C9CYP3A4FFAR4 | |
| SCHEMBL15073230 | 0.86 | DGAT1 (0.66) | DGAT1KCNH2CYP2C9CYP3A4ADORA2A | |
| SCHEMBL15073358 | 0.86 | DGAT1 (0.56) | DGAT1KCNH2CYP2C9CYP3A4FFAR4 | |
| SCHEMBL15073323 | 0.86 | DGAT1 (0.56) | DGAT1KCNH2CYP2C9CYP3A4FFAR4 | |
| SCHEMBL15073188 | 0.85 | DGAT1 (0.59) | DGAT1KCNH2CYP2C9CYP3A4FFAR4 | |
| SCHEMBL15073355 | 0.85 | DGAT1 (0.57) | DGAT1KCNH2CYP2C9CYP3A4FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013096093-A1 | COMPOUNDS AS DGAT-1 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2013-06-27 | — | — | WO | disclosed |