Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 19/20 | 0.58 |
| ▸ | SOAT1 | P35610 | 3/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15073180 | 0.89 | DGAT1 (0.62) | DGAT1SOAT1 | |
| SCHEMBL3538810 | 0.79 | IDO1 (0.57) | DGAT1SOAT1NPC1RAB9A | |
| SCHEMBL17318281 | 0.79 | IDO1 (0.57) | DGAT1SOAT1NPC1RAB9A | |
| SCHEMBL3538808 | 0.79 | IDO1 (0.57) | DGAT1SOAT1NPC1RAB9A | |
| SCHEMBL4940938 | 0.78 | DGAT1 (0.59) | DGAT1SOAT1 | |
| SCHEMBL4939294 | 0.77 | DGAT1 (0.53) | DGAT1SOAT1 | |
| SCHEMBL902399 | 0.76 | DGAT1 (0.60) | DGAT1SOAT1 | |
| SCHEMBL15073300 | 0.76 | ESR2 (0.42) | DGAT1SOAT1NPC1RAB9A | |
| SCHEMBL902462 | 0.75 | DGAT1 (0.73) | DGAT1SOAT1 | |
| SCHEMBL16649074 | 0.74 | DGAT1 (0.60) | DGAT1SOAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013096093-A1 | COMPOUNDS AS DGAT-1 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2013-06-27 | — | — | WO | disclosed |