Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 20/20 | 0.69 |
| ▸ | AKT1 | P31749 | 10/20 | 0.67 |
| ▸ | AURKA | O14965 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15054840 | 0.82 | RPS6KB1 (1.00) | RPS6KB1AKT1 | |
| SCHEMBL15054839 | 0.82 | RPS6KB1 (1.00) | RPS6KB1AKT1AURKA | |
| SCHEMBL15054836 | 0.82 | RPS6KB1 (1.00) | RPS6KB1AKT1AURKA | |
| SCHEMBL15054993 | 0.82 | RPS6KB1 (1.00) | RPS6KB1AKT1AURKA | |
| SCHEMBL15054173 | 0.80 | RPS6KB1 (1.00) | RPS6KB1AKT1 | |
| SCHEMBL15054683 | 0.80 | RPS6KB1 (1.00) | RPS6KB1AKT1 | |
| SCHEMBL27992575 | 0.80 | RPS6KB1 (0.83) | RPS6KB1AKT1 | |
| SCHEMBL15054800 | 0.80 | RPS6KB1 (1.00) | RPS6KB1AKT1 | |
| SCHEMBL15054481 | 0.80 | RPS6KB1 (1.00) | RPS6KB1AKT1 | |
| SCHEMBL27992577 | 0.79 | RPS6KB1 (0.77) | RPS6KB1AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013096194-A1 | NOVEL HETEROCYCLIC CARBOXAMIDES AS MODULATORS OF KINASE ACTIVITY | MERCK PATENT GMBH (DE) | 2013-06-27 | — | — | WO | disclosed |