Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13983226 | 0.77 | TSHR (0.58) | TDP1TSHRSMN1; SMN2GPR35HSD17B10 | |
| SCHEMBL31565807 | 0.76 | HSD17B10 (0.54) | TDP1TSHRSMN1; SMN2GPR35HSD17B10 | |
| SCHEMBL11027917 | 0.76 | HSD17B10 (0.54) | TDP1TSHRSMN1; SMN2GPR35HSD17B10 | |
| SCHEMBL13982690 | 0.75 | HPGD (0.47) | TDP1TSHRSMN1; SMN2GPR35ALDH1A1 | |
| SCHEMBL13982728 | 0.74 | TDP1 (0.45) | TDP1TSHRSMN1; SMN2GPR35HSD17B10 | |
| SCHEMBL3223967 | 0.74 | TDP1 (0.45) | TDP1TSHRSMN1; SMN2GPR35HSD17B10 | |
| SCHEMBL10724399 | 0.74 | TDP1 (0.45) | TDP1TSHRSMN1; SMN2GPR35HSD17B10 | |
| SCHEMBL16953606 | 0.73 | TSHR (0.46) | TDP1TSHRSMN1; SMN2GPR35HSD17B10 | |
| SCHEMBL16956383 | 0.71 | TDP1 (0.42) | TDP1TSHRSMN1; SMN2GPR35HSD17B10 | |
| SCHEMBL28942174 | 0.71 | TDP1 (0.39) | TDP1TSHRSMN1; SMN2HSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3103799-A1 | QUINAZOLINE DERIVATIVES | OSI Pharmaceuticals, LLC (US) | 2016-12-14 | — | — | EP | disclosed |
| EP-2163546-B1 | Quinazoline derivatives | PFIZER PROD INC (US) | 2016-06-01 | — | — | EP | disclosed |
| EP-2295415-A1 | Quinazoline derivatives | OSI Pharmaceuticals, Inc. (US) | 2011-03-16 | — | — | EP | disclosed |