Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.56 |
| ▸ | GAK | O14976 | 3/20 | 0.56 |
| ▸ | FBP1 | P09467 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.52 |
| ▸ | BUB1 | O43683 | 2/20 | 0.52 |
| ▸ | STK10 | O94804 | 2/20 | 0.52 |
| ▸ | MAP3K1 | Q13233 | 2/20 | 0.52 |
| ▸ | PIP4K2C | Q8TBX8 | 2/20 | 0.52 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.52 |
| ▸ | CARS1 | P49589 | 1/20 | 0.52 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.52 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.52 |
| ▸ | ABL1 | P00519 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | RAF1 | P04049 | 2/20 | 0.52 |
| ▸ | SRC | P12931 | 2/20 | 0.52 |
| ▸ | ABL2 | P42684 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1507541 | 0.91 | EGFR (0.57) | EGFRGAKFBP1MAPTALDH1A1 | |
| SCHEMBL1507596 | 0.87 | EGFR (0.57) | EGFRGAKFBP1MAPTALDH1A1 | |
| SCHEMBL1507783 | 0.86 | EGFR (0.64) | EGFRGAKFBP1MAPTALDH1A1 | |
| SCHEMBL1507723 | 0.86 | EGFR (0.56) | EGFRGAKFBP1MAPTALDH1A1 | |
| SCHEMBL1507524 | 0.83 | EGFR (0.74) | EGFRGAKFBP1MAPTALDH1A1 | |
| SCHEMBL1507757 | 0.82 | FBP1 (0.62) | EGFRGAKFBP1MAPTALDH1A1 | |
| Hydrochloric Acid SCHEMBL18297961 | 0.82 | EGFR (0.63) | EGFRGAKFBP1MAPTALDH1A1 | |
| SCHEMBL7867404 | 0.81 | FBP1 (0.56) | EGFRGAKFBP1MAPTALDH1A1 | |
| SCHEMBL1507662 | 0.80 | FBP1 (0.57) | EGFRGAKFBP1MAPTALDH1A1 | |
| SCHEMBL27370467 | 0.80 | EGFR (0.69) | EGFRGAKFBP1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3103799-A1 | QUINAZOLINE DERIVATIVES | OSI Pharmaceuticals, LLC (US) | 2016-12-14 | — | — | EP | disclosed |
| EP-2163546-B1 | Quinazoline derivatives | PFIZER PROD INC (US) | 2016-06-01 | — | — | EP | disclosed |
| EP-2295415-A1 | Quinazoline derivatives | OSI Pharmaceuticals, Inc. (US) | 2011-03-16 | — | — | EP | disclosed |
| EP-2163546-A1 | Quinazoline derivatives | Pfizer Products Incorporated (US) | 2010-03-17 | — | — | EP | disclosed |
| EP-0817775-B1 | QUINAZOLINE DERIVATIVES | PFIZER (US) | 2001-09-12 | — | — | EP | disclosed |
| EP-1110953-A1 | Quinazoline derivatives | PFIZER INC. (US) | 2001-06-27 | — | — | EP | disclosed |