Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 18/20 | 1.00 |
| ▸ | JAK3 | P52333 | 8/20 | 0.57 |
| ▸ | JAK2 | O60674 | 7/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15077613 | 1.00 | JAK1 (1.00) | JAK1JAK3JAK2 | |
| SCHEMBL15077538 | 1.00 | JAK1 (1.00) | JAK1JAK3JAK2 | |
| SCHEMBL16227819 | 1.00 | JAK1 (1.00) | JAK1JAK3JAK2 | |
| SCHEMBL16227997 | 1.00 | JAK1 (1.00) | JAK1JAK3JAK2 | |
| SCHEMBL16192213 | 0.87 | JAK1 (0.81) | JAK1JAK3JAK2 | |
| SCHEMBL15077677 | 0.85 | JAK1 (1.00) | JAK1JAK3JAK2 | |
| SCHEMBL15077590 | 0.85 | JAK1 (1.00) | JAK1JAK3JAK2 | |
| SCHEMBL15077661 | 0.85 | JAK1 (0.73) | JAK1JAK3JAK2 | |
| SCHEMBL18522427 | 0.84 | JAK1 (0.76) | JAK1JAK3JAK2 | |
| SCHEMBL21383001 | 0.84 | JAK1 (0.72) | JAK1JAK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2796460-B1 | PYRROLE SIX-MEMBERED HETEROARYL RING DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICINAL USES THEREOF | JIANGSU HENGRUI MEDICINE CO (CN) | 2018-07-04 | — | — | EP | disclosed |
| EP-2796460-A1 | PYRROLE SIX-MEMBERED HETEROARYL RING DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICINAL USES THEREOF | Jiangsu Hengrui Medicine Co. Ltd. (CN) | 2014-10-29 | — | — | EP | disclosed |
| WO-2013091539-A1 | PYRROLE SIX-MEMBERED HETEROARYL RING DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICINAL USES THEREOF | 江苏恒瑞医药股份有限公司 (CN) | 2013-06-27 | — | — | WO | disclosed |