Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 19/20 | 0.73 |
| ▸ | JAK3 | P52333 | 9/20 | 0.59 |
| ▸ | JAK2 | O60674 | 10/20 | 0.55 |
| ▸ | TYK2 | P29597 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30746027 | 0.91 | JAK1 (0.72) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL21383001 | 0.91 | JAK1 (0.72) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL15077655 | 0.87 | JAK1 (0.69) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL15077707 | 0.87 | JAK1 (0.69) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL15077565 | 0.85 | JAK1 (0.59) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL16227819 | 0.85 | JAK1 (1.00) | JAK1JAK3JAK2 | |
| SCHEMBL15077538 | 0.85 | JAK1 (1.00) | JAK1JAK3JAK2 | |
| SCHEMBL15077656 | 0.85 | JAK1 (1.00) | JAK1JAK3JAK2 | |
| SCHEMBL15077613 | 0.85 | JAK1 (1.00) | JAK1JAK3JAK2 | |
| SCHEMBL16227997 | 0.85 | JAK1 (1.00) | JAK1JAK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013091539-A1 | PYRROLE SIX-MEMBERED HETEROARYL RING DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICINAL USES THEREOF | 江苏恒瑞医药股份有限公司 (CN) | 2013-06-27 | — | — | WO | disclosed |