SCHEMBL1507913

NC(=O)C(CCC(F)(F)F)N(Cc1ccc(C(N)=NO)cc1F)S(=O)(=O)c1ccc(Cl)cc1.NC(=O)[C@@H](CCC(F)(F)F)N[C@@H](c1ccc(-c2ncon2)cc1F)S(=O)(=O)c1ccc(Cl)cc1

nearest known ligand 0.71

Predicted protein targets (top 6)

	gene	UniProt	supporting neighbours	confidence
▸	PSEN1	P49768	20/20	0.71

▸	PSEN2	P49810	20/20	0.71

▸	APH1B	Q8WW43	20/20	0.71

▸	NCSTN	Q92542	20/20	0.71

▸	APH1A	Q96BI3	20/20	0.71

▸	PSENEN	Q9NZ42	20/20	0.71

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Avagacestat SCHEMBL381851	0.84	PSEN1 (1.00)	PSEN1PSEN2APH1BNCSTNAPH1A
Avagacestat SCHEMBL310019	0.84	PSEN1 (1.00)	PSEN1PSEN2APH1BNCSTNAPH1A
Avagacestat SCHEMBL29392347	0.84	PSEN1 (1.00)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL379111	0.84	PSEN1 (0.64)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL1642920	0.80	PSEN1 (0.71)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL310470	0.80	PSEN1 (0.71)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL11939689	0.78	PSEN1 (0.87)	PSEN1PSEN2APH1BNCSTNAPH1A
Avagacestat SCHEMBL12227575	0.78	PSEN1 (0.85)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL1643466	0.73	PSEN1 (0.69)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL1464862	0.73	PSEN1 (0.76)	PSEN1PSEN2APH1BNCSTNAPH1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-2295417-A1	Novel intermediates useful for preparing alpha-(n-sulfonamido)acetamide compound	Bristol-Myers Squibb Company (US)	2011-03-16	—	—	EP	disclosed