SCHEMBL379111

SCHEMBL379111

NC(=O)[C@@H](CCC(F)(F)F)NC(c1ccc(-c2ncon2)cc1F)S(=O)(=O)c1ccc(Cl)cc1

nearest known ligand 0.64

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
PSEN1 P49768 19/20 0.64
PSEN2 P49810 19/20 0.64
APH1B Q8WW43 19/20 0.64
NCSTN Q92542 19/20 0.64
APH1A Q96BI3 19/20 0.64
PSENEN Q9NZ42 19/20 0.64
KAT6A Q92794 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1507913 0.84 PSEN1 (0.71) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL462471 0.74 PSEN1 (0.68) PSEN1PSEN2APH1BNCSTNAPH1A
Avagacestat SCHEMBL310019 0.74 PSEN1 (1.00) PSEN1PSEN2APH1BNCSTNAPH1A
Avagacestat SCHEMBL381851 0.74 PSEN1 (1.00) PSEN1PSEN2APH1BNCSTNAPH1A
Avagacestat SCHEMBL29392347 0.74 PSEN1 (1.00) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL15062259 0.74 PSEN1 (0.59) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL11939689 0.70 PSEN1 (0.87) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL381852 0.67 PSEN1 (0.65) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL12502549 0.65 PSEN1 (0.48) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL310015 0.65 PSEN1 (0.48) PSEN1PSEN2APH1BNCSTNAPH1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2419086-A2 BIOAVAILABLE COMPOSITIONS OF AMORPHOUS ALPHA-(N-SULFONAMIDO)ACETAMIDE COMPOUND Bristol-Myers Squibb Company (US) 2012-02-22 EP claimed
WO-2010120662-A2 BIOAVAILABLE COMPOSITIONS OF AMORPHOUS ALPHA-(N-SULFONAMIDO)ACETAMIDE COMPOUND BRISTOL-MYERS SQUIBB COMPANY (US) 2010-10-21 WO claimed
EP-2419090-B1 BIOAVAILABLE CAPSULE COMPOSITIONS OF AMORPHOUS ALPHA-(N-SULFONAMIDO)ACETAMIDE COMPOUND BRISTOL MYERS SQUIBB CO (US) 2013-02-13 EP disclosed
EP-2295417-B1 Novel intermediates useful for preparing alpha-(n-sulfonamido)acetamide compound BRISTOL MYERS SQUIBB CO (US) 2012-07-04 EP disclosed
EP-2419090-A1 BIOAVAILABLE CAPSULE COMPOSITIONS OF AMORPHOUS ALPHA-(N-SULFONAMIDO)ACETAMIDE COMPOUND Bristol-Myers Squibb Company (US) 2012-02-22 EP disclosed
EP-2419086-A2 BIOAVAILABLE COMPOSITIONS OF AMORPHOUS ALPHA-(N-SULFONAMIDO)ACETAMIDE COMPOUND Bristol-Myers Squibb Company (US) 2012-02-22 EP disclosed
EP-2408450-A1 A NOVEL ALPHA-(N-SULFONAMIDO)ACETAMIDE COMPOUND AS AN INHIBITOR OF BETA AMYLOID PEPTIDE PRODUCTION Bristol-Myers Squibb Company (US) 2012-01-25 EP disclosed
EP-2408757-A1 NOVEL ALPHA-(N-SULFONAMIDO)ACETAMIDE COMPOUNDS INCORPORATING DEUTERIUM AS INHIBITORS OF BETA AMYLOID PEPTIDE PRODUCTION A NOVEL ALPHA-(N-SULFONAMIDO) ACETAMIDE COMPOUND INCORPORATING DEUTERIUM AS INHIBITOR OF BETA AMYLOID PEPTIDE PRODUCTION Bristol-Myers Squibb Company (US) 2012-01-25 EP disclosed
EP-2295417-A1 Novel intermediates useful for preparing alpha-(n-sulfonamido)acetamide compound Bristol-Myers Squibb Company (US) 2011-03-16 EP disclosed
EP-2205575-B1 A NOVEL ALPHA-(N-SULFONAMIDO)ACETAMIDE COMPOUND AS AN INHIBITOR OF BETA AMYLOID PEPTIDE PRODUCTION BRISTOL MYERS SQUIBB CO (US) 2011-03-16 EP disclosed
WO-2010120662-A2 BIOAVAILABLE COMPOSITIONS OF AMORPHOUS ALPHA-(N-SULFONAMIDO)ACETAMIDE COMPOUND BRISTOL-MYERS SQUIBB COMPANY (US) 2010-10-21 WO disclosed
WO-2010120755-A1 BIOAVAILABLE CAPSULE COMPOSITIONS OF AMORPHOUS ALPHA-(N-SULFONAMIDO)ACETAMIDE COMPOUND BRISTOL-MYERS SQUIBB COMPANY (US) 2010-10-21 WO disclosed
WO-2010107435-A1 A NOVEL ALPHA-(N-SULFONAMIDO)ACETAMIDE COMPOUND AS AN INHIBITOR OF BETA AMYLOID PEPTIDE PRODUCTION BRISTOL-MYERS SQUIBB COMPANY (US) 2010-09-23 WO disclosed
WO-2010107984-A1 NOVEL ALPHA-(N-SULFONAMIDO)ACETAMIDE COMPOUNDS INCORPORATING DEUTERIUM AS INHIBITORS OF BETA AMYLOID PEPTIDE PRODUCTION A NOVEL ALPHA-(N-SULFONAMIDO) ACETAMIDE COMPOUND INCORPORATING DEUTERIUM AS INHIBITOR OF BETA AMYLOID PEPTIDE PRODUCTION BRISTOL-MYERS SQUIBB COMPANY (US) 2010-09-23 WO disclosed
EP-2205575-A1 A NOVEL ALPHA-(N-SULFONAMIDO)ACETAMIDE COMPOUND AS AN INHIBITOR OF BETA AMYLOID PEPTIDE PRODUCTION Bristol-Myers Squibb Company (US) 2010-07-14 EP disclosed
WO-2009058552-A1 A NOVEL ALPHA-(N-SULFONAMIDO)ACETAMIDE COMPOUND AS AN INHIBITOR OF BETA AMYLOID PEPTIDE PRODUCTION BRISTOL-MYERS SQUIBB COMPANY (US) 2009-05-07 WO disclosed