Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.41 |
| ▸ | HPGD | P15428 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | DAO | P14920 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11886185 | 0.81 | KDM4E (0.41) | CSNK2A2KDRCSNK2BCSNK2A1KDM4E | |
| SCHEMBL11888024 | 0.79 | HPGD (0.44) | CSNK2A2KDRCSNK2BCSNK2A1KDM4E | |
| SCHEMBL9925990 | 0.79 | KDM4E (0.67) | CSNK2A2KDRCSNK2BCSNK2A1KDM4E | |
| SCHEMBL261464 | 0.76 | CSNK2A2 (0.45) | CSNK2A2KDRCSNK2BCSNK2A1KDM4E | |
| SCHEMBL3210679 | 0.76 | CISD2 (0.47) | CSNK2A2KDRCSNK2BCSNK2A1KDM4E | |
| SCHEMBL18051446 | 0.76 | CSNK2A2 (0.45) | CSNK2A2KDRCSNK2BCSNK2A1KDM4E | |
| SCHEMBL16302070 | 0.76 | DAO (0.69) | CSNK2A2KDRCSNK2BCSNK2A1KDM4E | |
| SCHEMBL7431737 | 0.73 | CSNK2A2 (0.43) | CSNK2A2KDRCSNK2BCSNK2A1KDM4E | |
| SCHEMBL16901555 | 0.73 | HPGD (0.54) | CSNK2A2KDRCSNK2BCSNK2A1KDM4E | |
| SCHEMBL14391003 | 0.72 | KDM4E (0.47) | CSNK2A2KDRCSNK2BCSNK2A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078002-B1 | 2-AMINOTHIAZOLE-4-CARBOXYLIC AMIDES AS PROTEIN KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2013-08-28 | — | — | EP | disclosed |
| US-8476278-B2 | Thiazole Derivatives as protein kinase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2013-07-02 | — | — | US | disclosed |