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Sugi Predict / Targets / CISD2

CISD2

CDGSH iron-sulfur domain-containing protein 2 · Q8N5K1 · CISD2 on Sugi Atlas →

1,781 patent compounds predicted against CISD2, 988 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL8290343 SCHEMBL8290343 1.00 19/20
SCHEMBL14299729 SCHEMBL14299729 0.70 16/20
SCHEMBL8288705 SCHEMBL8288705 1.00 15/20
SCHEMBL15715922 SCHEMBL15715922 0.80 15/20
SCHEMBL3455650 SCHEMBL3455650 0.59 13/20
SCHEMBL3239048 SCHEMBL3239048 0.61 12/20
SCHEMBL9400300 SCHEMBL9400300 0.61 12/20
SCHEMBL3056486 SCHEMBL3056486 0.54 12/20
SCHEMBL1540012 SCHEMBL1540012 0.58 11/20
SCHEMBL1063435 SCHEMBL1063435 0.51 11/20
SCHEMBL14235639 SCHEMBL14235639 0.45 11/20
SCHEMBL9400304 SCHEMBL9400304 0.79 10/20
SCHEMBL10478238 SCHEMBL10478238 0.46 10/20
SCHEMBL16689477 SCHEMBL16689477 0.42 10/20
SCHEMBL8290684 SCHEMBL8290684 0.83 9/20
SCHEMBL11307553 SCHEMBL11307553 0.61 9/20
SCHEMBL3803747 SCHEMBL3803747 0.48 9/20
SCHEMBL3059204 SCHEMBL3059204 0.45 9/20
SCHEMBL5160762 SCHEMBL5160762 0.42 9/20
SCHEMBL13236165 SCHEMBL13236165 0.69 8/20

Clinical trials — most relevant to CISD2 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Effect of Pioglitazone Administered to Patients With Friedreich's Ataxia: Proof of Concept PHASE3COMPLETED
Testing the Combination of MLN4924 (Pevonedistat), Carboplatin, and Paclitaxel in Patients With Advanced Non-small Cell Lung Cancer (NSCLC) Who Have Previously Been Treated With Immunotherapy PHASE2ACTIVE_NOT_RECRUITING
The Effects of a Glutathione Precursor (FT061452),on Serum and Intracellular Glutathione Levels PHASE1COMPLETED
Tolerability of Enteral NAC in Infants PHASE1NOT_YET_RECRUITING
Treatment Duration Increment and Pharmacodynamic Study of CX-4945 in Patients With Basal Cell Carcinoma (BCC) PHASE1COMPLETED
Investigations Into ISCU Myopathy or Iron Sulfur Scaffold U Protein Myopathy nanCOMPLETED
Dietary Effects of Sulfur Amino Acids nanCOMPLETED
Tecfidera Diffusion Tensor Imaging nanCOMPLETED
Effect of Sulfur Amino Acid Depletion and Acetaminophen on Plasma Glutatione nanCOMPLETED
Natural History Study of FDXR Mutation-related Mitochondriopathy nanCOMPLETED
Incidence of Iron Deficiency in Polycythemia Vera (PV) and Association With Disease Features nanUNKNOWN
Cerebellar Mutism Syndrome Study nanRECRUITING
Biocollection in MyeloDysplastic Syndrome (P-MDS) nanRECRUITING
Hemochromatosis and Iron Overload Screening Study (HEIRS) nanCOMPLETED
Identifying Genetic Causes of IC/BPS nanRECRUITING
Plant-based Diets and Body Weight and Selected Metabolic Parameters Management in Obese Patients. nanCOMPLETED
Assessing the Polygenic Burden of Rare Disruptive Mutations in Parkinson's Disease nanUNKNOWN
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA nanRECRUITING
Genetic Characterization of Parkinson's Disease nanCOMPLETED
Genetic Study of Age-Related Macular Degeneration nanCOMPLETED
Thiol/Disulphide Homeostasis in Unexplained Infertility nanCOMPLETED
Prevalence of a Non-Expressing 11B Mutation in Aka Peoples of the Central African Republic nanCOMPLETED
Expression of Fas Protein in Skin Biopsies of Participants With Scarring Alopecia nanCOMPLETED
Impact of Seasonal Malaria Chemoprevention on Immunity Against Malaria Among Children in Northern Benin nanCOMPLETED
Identification of Acute Intermittent Porphyria Modifying Genes nanRECRUITING
Zinc and the Synthesis of Zinc Binding Proteins (Protocol B) nanCOMPLETED
Sodium Transport: Genetics and Hypertension nanCOMPLETED
GDF 15 in Sickle Cell Disease and Hereditary Spherocytosis nanUNKNOWN
Molecular Epidemiology of Parkinson's Disease nanCOMPLETED
Genetic Variants Associated With Adolescent Suicide Attempts nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a CISD2 binder may also engage these)

ProteinNameSimilarity
Q05B71 — 1.000 Q05B71 →
Q9CQB5 — 1.000 Q9CQB5 →
Q6PCF8 — 1.000 Q6PCF8 →
Q6AZG1 — 1.000 Q6AZG1 →
B3RML8 — 0.999 B3RML8 →
B4K5X8 — 0.998 B4K5X8 →
Q29BX8 — 0.997 Q29BX8 →
B9EPI1 — 0.997 B9EPI1 →
Q5I027 — 0.997 Q5I027 →
Q7T326 — 0.996 Q7T326 →
C1C524 — 0.996 C1C524 →
B4GPI0 — 0.996 B4GPI0 →
B4JYJ2 — 0.995 B4JYJ2 →
B5X8S2 — 0.995 B5X8S2 →
B4MBU8 — 0.995 B4MBU8 →
B4PQ50 — 0.995 B4PQ50 →
C1BI29 — 0.995 C1BI29 →
B4QZI8 — 0.995 B4QZI8 →
B4HZ81 — 0.994 B4HZ81 →
B3P5J1 — 0.993 B3P5J1 →
C1BGG0 — 0.993 C1BGG0 →
B4NFN4 — 0.991 B4NFN4 →
Q9VAM6 — 0.991 Q9VAM6 →
B3M1H7 — 0.990 B3M1H7 →
C3ZWH9 — 0.989 C3ZWH9 →
C4A0P0 — 0.987 C4A0P0 →
DHX29 ATP-dependent RNA helicase DHX29 0.985 landscape →
Q08960 — 0.985 Q08960 →
Q80KJ8 — 0.984 Q80KJ8 →
A8NJ91 — 0.984 A8NJ91 →