Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 6/20 | 0.63 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.52 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.44 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.43 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.43 |
| ▸ | ITGAL | P20701 | 1/20 | 0.43 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.43 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.43 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.43 |
| ▸ | MC1R | Q01726 | 2/20 | 0.43 |
| ▸ | MC4R | P32245 | 1/20 | 0.43 |
| ▸ | MC5R | P33032 | 1/20 | 0.43 |
| ▸ | MC3R | P41968 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15080457 | 0.82 | REN (0.54) | RENSLC15A2ACE2SCN9AITGB2 | |
| SCHEMBL12711228 | 0.81 | REN (0.54) | RENSLC15A2SCN9AITGB2ICAM1 | |
| SCHEMBL12632551 | 0.81 | REN (0.53) | RENSLC15A2ACE2SCN9AITGB2 | |
| SCHEMBL12537131 | 0.80 | REN (0.55) | RENSLC15A2ACE2SCN9AITGB2 | |
| SCHEMBL18402423 | 0.80 | REN (0.60) | RENSLC15A2ACE2ERAP2ERAP1 | |
| SCHEMBL13563440 | 0.80 | REN (0.75) | RENACE2 | |
| SCHEMBL12085739 | 0.79 | REN (0.45) | RENSLC15A2ACE2SCN9AITGB2 | |
| SCHEMBL29429145 | 0.79 | SLC15A2 (0.63) | RENSLC15A2MC4R | |
| SCHEMBL29531079 | 0.79 | SLC15A2 (0.63) | RENSLC15A2MC4R | |
| SCHEMBL23692651 | 0.78 | REN (0.49) | RENSLC15A2ERAP2ERAP1LNPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8476240-B2 | Histidine related compounds for identifying and blocking amyloid beta ion channels | THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. (US) | 2013-07-02 | — | — | US | disclosed |