Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.77 |
| ▸ | MEN1 | O00255 | 4/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.76 |
| ▸ | APEX1 | P27695 | 2/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.76 |
| ▸ | POLB | P06746 | 1/20 | 0.76 |
| ▸ | MAPT | P10636 | 1/20 | 0.76 |
| ▸ | THRB | P10828 | 1/20 | 0.76 |
| ▸ | RECQL | P46063 | 1/20 | 0.76 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.76 |
| ▸ | XPA | P23025 | 4/20 | 0.74 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.71 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.68 |
| ▸ | GALK1 | P51570 | 1/20 | 0.68 |
| ▸ | EP300 | Q09472 | 8/20 | 0.67 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.65 |
| ▸ | BRAF | P15056 | 1/20 | 0.65 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.65 |
| ▸ | GSK3A | P49840 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19654564 | 0.94 | SIRT5 (0.74) | SIRT5MEN1KMT2AAPEX1KDM4E | |
| SCHEMBL13225257 | 0.94 | MEN1 (0.77) | SIRT5MEN1KMT2AAPEX1KDM4E | |
| SCHEMBL6397382 | 0.93 | XPA (0.81) | SIRT5MEN1KMT2AAPEX1KDM4E | |
| SCHEMBL6397378 | 0.93 | XPA (0.81) | SIRT5MEN1KMT2AAPEX1KDM4E | |
| SCHEMBL12717702 | 0.89 | SIRT5 (0.69) | SIRT5MEN1KMT2AAPEX1KDM4E | |
| SCHEMBL13225258 | 0.89 | EP300 (0.72) | SIRT5MEN1KMT2AAPEX1KDM4E | |
| SCHEMBL19644314 | 0.89 | MEN1 (0.79) | SIRT5MEN1KMT2AAPEX1KDM4E | |
| SCHEMBL19644315 | 0.89 | MEN1 (0.79) | SIRT5MEN1KMT2AAPEX1KDM4E | |
| SCHEMBL19652473 | 0.88 | GSK3A (0.77) | SIRT5MEN1KMT2AAPEX1KDM4E | |
| SCHEMBL20840289 | 0.86 | MEN1 (0.90) | SIRT5MEN1KMT2AAPEX1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9138439-B2 | Methods and compositions for modulating P300/CBP activity | THE WISTAR INSTITUTE (US) | 2015-09-22 | — | — | US | disclosed |
| US-8476458-B2 | Methods and compositions for modulating P300/CBP activity | THE WISTAR INSTITUTE (US) | 2013-07-02 | — | — | US | disclosed |