Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 2/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.39 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.37 |
| ▸ | ATXN2 | Q99700 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2670198 | 1.00 | PDE4B (0.41) | PDE4BSMN1; SMN2NPC1RAB9ACTSL | |
| SCHEMBL31085684 | 0.90 | PDE4B (0.44) | PDE4BSMN1; SMN2NPC1RAB9ACTSL | |
| SCHEMBL31085683 | 0.90 | PDE4B (0.44) | PDE4BSMN1; SMN2NPC1RAB9ACTSL | |
| SCHEMBL2670241 | 0.85 | PDE4B (0.45) | PDE4BSMN1; SMN2NPC1RAB9ACTSL | |
| SCHEMBL2670278 | 0.85 | PDE4B (0.45) | PDE4BSMN1; SMN2NPC1RAB9ACTSL | |
| SCHEMBL14346460 | 0.85 | PDE4B (0.45) | PDE4BSMN1; SMN2NPC1RAB9ACTSL | |
| SCHEMBL15063097 | 0.85 | PDE4B (0.45) | PDE4BSMN1; SMN2NPC1RAB9ACTSL | |
| SCHEMBL2670238 | 0.85 | PDE4B (0.45) | PDE4BSMN1; SMN2NPC1RAB9ACTSL | |
| SCHEMBL2670432 | 0.85 | PDE4B (0.45) | PDE4BSMN1; SMN2NPC1RAB9ACTSL | |
| SCHEMBL17105494 | 0.85 | CTSL (0.44) | PDE4BSMN1; SMN2NPC1RAB9ACTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097400-B1 | FUSED SUBSTITUTED AMINOPYRROLIDINE DERIVATIVE | DAIICHI SANKYO CO LTD (JP) | 2013-07-03 | — | — | EP | disclosed |