Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.67 |
| ▸ | FLT4 | P35916 | 7/20 | 0.67 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.67 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.67 |
| ▸ | TEK | Q02763 | 3/20 | 0.67 |
| ▸ | AURKA | O14965 | 3/20 | 0.67 |
| ▸ | AXL | P30530 | 6/20 | 0.65 |
| ▸ | EGFR | P00533 | 7/20 | 0.58 |
| ▸ | FLT1 | P17948 | 5/20 | 0.58 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.58 |
| ▸ | RET | P07949 | 3/20 | 0.58 |
| ▸ | PLK4 | O00444 | 2/20 | 0.58 |
| ▸ | GAK | O14976 | 2/20 | 0.58 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.58 |
| ▸ | ERN1 | O75460 | 2/20 | 0.58 |
| ▸ | STK10 | O94804 | 2/20 | 0.58 |
| ▸ | FYN | P06241 | 2/20 | 0.58 |
| ▸ | YES1 | P07947 | 2/20 | 0.58 |
| ▸ | LYN | P07948 | 2/20 | 0.58 |
| ▸ | MET | P08581 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15084515 | 0.94 | KDR (0.66) | KDRFLT4AURKBPDGFRBTEK | |
| SCHEMBL15084560 | 0.94 | KDR (0.66) | KDRFLT4AURKBPDGFRBTEK | |
| SCHEMBL15084599 | 0.93 | ABCB11 (0.67) | KDRFLT4AURKBPDGFRBTEK | |
| SCHEMBL2744735 | 0.91 | AXL (0.78) | KDRFLT4AURKBPDGFRBTEK | |
| SCHEMBL30001610 | 0.91 | AXL (0.78) | KDRFLT4AURKBPDGFRBTEK | |
| SCHEMBL15084619 | 0.91 | AXL (0.78) | KDRFLT4AURKBPDGFRBTEK | |
| SCHEMBL4031626 | 0.89 | KDR (0.70) | KDRFLT4AURKBPDGFRBTEK | |
| SCHEMBL5570163 | 0.88 | AXL (0.73) | KDRFLT4AURKBPDGFRBTEK | |
| SCHEMBL698905 | 0.87 | AXL (0.84) | KDRAURKBPDGFRBAURKAAXL | |
| SCHEMBL29631712 | 0.86 | AXL (0.71) | KDRFLT4AURKBPDGFRBTEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013097753-A1 | FUSED HETEROCYCLIC DERIVATIVE AND APPLICATION THEREOF | 江苏先声药业有限公司 (CN) | 2013-07-04 | — | — | WO | disclosed |