Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 4/20 | 0.71 |
| ▸ | EGFR | P00533 | 7/20 | 0.60 |
| ▸ | KDR | P35968 | 10/20 | 0.57 |
| ▸ | FLT4 | P35916 | 5/20 | 0.57 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.57 |
| ▸ | FLT1 | P17948 | 5/20 | 0.57 |
| ▸ | MET | P08581 | 5/20 | 0.57 |
| ▸ | RET | P07949 | 4/20 | 0.56 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.56 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.56 |
| ▸ | SRC | P12931 | 3/20 | 0.55 |
| ▸ | GAK | O14976 | 2/20 | 0.55 |
| ▸ | EPHB6 | O15197 | 2/20 | 0.55 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.55 |
| ▸ | STK10 | O94804 | 2/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.55 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.55 |
| ▸ | ABL1 | P00519 | 2/20 | 0.55 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.55 |
| ▸ | LCK | P06239 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29631712 | 1.00 | AXL (0.71) | AXLEGFRKDRFLT4FGFR1 | |
| SCHEMBL30001610 | 0.96 | AXL (0.78) | AXLEGFRKDRFLT4FGFR1 | |
| SCHEMBL15084619 | 0.96 | AXL (0.78) | AXLEGFRKDRFLT4FGFR1 | |
| SCHEMBL2744735 | 0.96 | AXL (0.78) | AXLEGFRKDRFLT4FGFR1 | |
| SCHEMBL5570163 | 0.92 | AXL (0.73) | AXLEGFRKDRFLT4FGFR1 | |
| SCHEMBL29631554 | 0.88 | SRC (0.60) | AXLEGFRKDRFLT4FGFR1 | |
| SCHEMBL23011638 | 0.88 | EGFR (0.62) | AXLEGFRKDRFLT4FGFR1 | |
| SCHEMBL14289192 | 0.88 | AXL (0.92) | AXLEGFRKDRFLT4FGFR1 | |
| SCHEMBL29908856 | 0.88 | AXL (0.92) | AXLEGFRKDRFLT4FGFR1 | |
| SCHEMBL1591152 | 0.88 | AXL (0.92) | AXLEGFRKDRFLT4FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013097753-A1 | FUSED HETEROCYCLIC DERIVATIVE AND APPLICATION THEREOF | 江苏先声药业有限公司 (CN) | 2013-07-04 | — | — | WO | disclosed |