Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 8/20 | 0.92 |
| ▸ | FLT3 | P36888 | 4/20 | 0.61 |
| ▸ | MET | P08581 | 10/20 | 0.60 |
| ▸ | EGFR | P00533 | 3/20 | 0.60 |
| ▸ | KDR | P35968 | 3/20 | 0.60 |
| ▸ | MST1R | Q04912 | 3/20 | 0.60 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.60 |
| ▸ | SRC | P12931 | 2/20 | 0.60 |
| ▸ | AURKA | O14965 | 2/20 | 0.60 |
| ▸ | LCK | P06239 | 2/20 | 0.60 |
| ▸ | CSF1R | P07333 | 2/20 | 0.60 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.60 |
| ▸ | FLT4 | P35916 | 2/20 | 0.60 |
| ▸ | TEK | Q02763 | 2/20 | 0.60 |
| ▸ | BTK | Q06187 | 2/20 | 0.60 |
| ▸ | PLK4 | O00444 | 1/20 | 0.60 |
| ▸ | STK25 | O00506 | 1/20 | 0.60 |
| ▸ | CIT | O14578 | 1/20 | 0.60 |
| ▸ | CHUK | O15111 | 1/20 | 0.60 |
| ▸ | MUSK | O15146 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1591152 | 1.00 | AXL (0.92) | AXLFLT3METEGFRKDR | |
| SCHEMBL14289192 | 1.00 | AXL (0.92) | AXLFLT3METEGFRKDR | |
| SCHEMBL14289180 | 0.96 | AXL (1.00) | AXLFLT3METEGFRKDR | |
| SCHEMBL166239 | 0.96 | AXL (1.00) | AXLFLT3METEGFRKDR | |
| SCHEMBL30000966 | 0.96 | AXL (1.00) | AXLFLT3METEGFRKDR | |
| SCHEMBL25118503 | 0.88 | AXL (0.72) | AXLFLT3METEGFRKDR | |
| SCHEMBL15084626 | 0.88 | AXL (0.71) | AXLFLT3METEGFRKDR | |
| SCHEMBL29631712 | 0.88 | AXL (0.71) | AXLFLT3METEGFRKDR | |
| SCHEMBL15262000 | 0.87 | AXL (0.85) | AXLFLT3METKDRMST1R | |
| SCHEMBL1591146 | 0.87 | AXL (0.71) | AXLFLT3METEGFRKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115916210-A | Pharmaceutical composition for preventing or treating small cell lung cancer associated with RON mutation and method of using the same | 伟迈可生物有限公司 | 2023-04-04 | — | — | CN | disclosed |
| EP-4154891-A1 | PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING NON-SMALL CELL LUNG CANCER ASSOCIATED WITH RON MUTATION, AND METHOD USING SAME | Wellmarker Bio Co., Ltd. (KR) | 2023-03-29 | — | — | EP | disclosed |
| EP-4154892-A1 | PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING SMALL-CELL LUNG CANCER ASSOCIATED WITH RON MUTANTS AND METHOD USING SAME | Wellmarker Bio Co., Ltd. (KR) | 2023-03-29 | — | — | EP | disclosed |
| EP-4154890-A1 | PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING PANCREATIC CANCER ASSOCIATED WITH RON MUTATION AND METHOD USING SAME | Wellmarker Bio Co., Ltd. (KR) | 2023-03-29 | — | — | EP | disclosed |
| CN-115003307-A | Pharmaceutical composition for preventing or treating cancers associated with KRAS mutations | 伟迈可生物有限公司 | 2022-09-02 | — | — | CN | disclosed |