Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ELANE | P08246 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2384929 | 0.84 | MAPT (0.44) | LMNAMAPTSMN1; SMN2POLBTDP1 | |
| SCHEMBL2384932 | 0.84 | MAPT (0.44) | LMNAMAPTSMN1; SMN2POLBTDP1 | |
| SCHEMBL2383748 | 0.84 | CYP19A1 (0.48) | LMNAMAPTPOLBNPSR1TSHR | |
| SCHEMBL2383745 | 0.84 | CYP19A1 (0.48) | LMNAMAPTPOLBNPSR1TSHR | |
| SCHEMBL9334698 | 0.83 | NPC1 (0.50) | LMNASMN1; SMN2POLBCES2CES1 | |
| SCHEMBL9334707 | 0.83 | NPC1 (0.50) | LMNASMN1; SMN2POLBCES2CES1 | |
| SCHEMBL9954776 | 0.81 | CES2 (0.61) | LMNAMAPTSMN1; SMN2POLBTDP1 | |
| SCHEMBL15084622 | 0.81 | KMT2A (0.55) | LMNAMAPTSMN1; SMN2TDP1CES2 | |
| SCHEMBL11763253 | 0.81 | CES2 (0.53) | LMNAMAPTSMN1; SMN2TDP1CES2 | |
| SCHEMBL11763264 | 0.81 | CES2 (0.53) | LMNAMAPTSMN1; SMN2TDP1CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013097753-A1 | FUSED HETEROCYCLIC DERIVATIVE AND APPLICATION THEREOF | 江苏先声药业有限公司 (CN) | 2013-07-04 | — | — | WO | disclosed |