SCHEMBL15085642

SCHEMBL15085642

N[C@H](Cc1cc(F)c(O)c(Cl)c1)C(=O)O

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRIA2 P42262 1/20 0.49
SIRT5 Q9NXA8 1/20 0.48
HSD17B10 Q99714 5/20 0.47
ALOX15 P16050 5/20 0.47
USP2 O75604 4/20 0.47
TDP1 Q9NUW8 4/20 0.47
HIF1A Q16665 4/20 0.47
SLC7A5 Q01650 3/20 0.47
ADORA3 P0DMS8 3/20 0.47
PTGS1 P23219 3/20 0.47
KDM4E B2RXH2 2/20 0.47
RECQL P46063 2/20 0.47
PTGS2 P35354 2/20 0.47
EGFR P00533 1/20 0.47
LCK P06239 1/20 0.47
FYN P06241 1/20 0.47
HTR2A P28223 1/20 0.47
MEN1 O00255 5/20 0.46
KMT2A Q03164 5/20 0.46
CYP3A4 P08684 4/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31083609 0.89 SLC7A5 (0.55) GRIA2SIRT5HSD17B10ALOX15USP2
SCHEMBL2121998 0.89 SLC7A5 (0.55) GRIA2SIRT5HSD17B10ALOX15USP2
SCHEMBL2122000 0.89 SLC7A5 (0.55) GRIA2SIRT5HSD17B10ALOX15USP2
SCHEMBL296874 0.89 SLC7A5 (0.55) GRIA2SIRT5HSD17B10ALOX15USP2
SCHEMBL296873 0.89 SLC7A5 (0.55) GRIA2SIRT5HSD17B10ALOX15USP2
Hydrochloric Acid SCHEMBL16007570 0.87 GRIA2 (0.53) GRIA2SIRT5HSD17B10ALOX15USP2
Hydrochloric Acid SCHEMBL16007571 0.87 GRIA2 (0.53) GRIA2SIRT5HSD17B10ALOX15USP2
SCHEMBL16095308 0.86 SLC7A5 (0.47) GRIA2SIRT5HSD17B10ALOX15USP2
SCHEMBL28489176 0.86 SLC7A5 (0.47) GRIA2SIRT5HSD17B10ALOX15USP2
SCHEMBL5281682 0.85 SLC7A5 (0.60) GRIA2SIRT5HSD17B10ALOX15USP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 226 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11931329-B2 Compositions and methods for treating anxiety-related disorders YAMO PHARMACEUTICALS LLC (US) 2024-03-19 US claimed
US-20240024268-A1 Methods for Dopamine Modulation in Human Neurologic Diseases SACKNER BERNSTEIN JONATHAN (US) 2024-01-25 US claimed
US-20240016815-A1 COMPOSITIONS AND METHODS FOR MODULATING CANCER IN NON-HUMAN MAMMALS HOFFMAN TECHNOLOGIES LLC 2024-01-18 US claimed
US-11806326-B2 Methods for dopamine modulation in human neurologic diseases SACKNER BERNSTEIN JONATHAN (US) 2023-11-07 US claimed
US-11786496-B2 Composition and methods for treating intestinal hyperpermeability YAMO PHARMACEUTICALS LLC (US) 2023-10-17 US claimed
US-20230141609-A1 Methods of Treating Amyotrophic Lateral Sclerosis and Symptoms YAMO PHARMACEUTICALS LLC (US) 2023-05-11 US claimed
US-20230040681-A1 COMPOSITIONS AND METHODS FOR TREATING ANXIETY-RELATED DISORDERS YAMO PHARMACEUTICALS LLC (US) 2023-02-09 US claimed
US-11534420-B2 Compositions and methods for treating cancer TYME, INC. (US) 2022-12-27 US claimed
CN-115515575-A Tyrosine derivatives for the modulation of cancer 迪美公司 2022-12-23 CN claimed
CN-114901272-A Sustained release preparation 霍夫曼技术有限责任公司 2022-08-12 CN claimed
WO-2015061288-A1 TYROSINE DERIVATIVES AND COMPOSITIONS COMPRISING THEM TYME, INC. (US) 2015-04-30 WO claimed
WO-2015061328-A2 COMPOSITIONS AND METHODS FOR TREATING INTESTINAL HYPERPERMEABILITY HOFFMAN STEVEN (US) 2015-04-30 WO claimed
US-20150111937-A1 Compositions and Methods for Treating Intestinal Hyperpermeability YAMO PHARMACEUTICALS LLC 2015-04-23 US claimed
US-20150111878-A1 COMPOSITIONS AND METHODS FOR TREATING INTESTINAL HYPERPERMEABILITY HOFFMAN STEVEN (US) 2015-04-23 US claimed
US-20150110735-A1 HIGH-SPEED CENTRIFUGAL MIXING DEVICES AND METHODS OF USE OXFORD FINANCE LLC, AS COLLATERAL AGENT 2015-04-23 US claimed
US-20150112116-A1 TYROSINE DERIVATIVES AND COMPOSITIONS COMPRISING THEM OXFORD FINANCE LLC, AS COLLATERAL AGENT 2015-04-23 US claimed
EP-2804599-A1 PHARMACEUTICAL COMPOSITIONS AND METHODS Tyme, Inc. (US) 2014-11-26 EP claimed
WO-2013109610-A1 PHARMACEUTICAL COMPOSITIONS AND METHODS HOFFMAN STEVEN (US) 2013-07-25 WO claimed
US-20130184214-A1 PHARMACEUTICAL COMPOSITIONS AND METHODS OXFORD FINANCE LLC, AS COLLATERAL AGENT 2013-07-18 US claimed
US-8481498-B1 Pharmaceutical compositions and methods OXFORD FINANCE LLC, AS COLLATERAL AGENT 2013-07-09 US claimed