Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 4/20 | 0.37 |
| ▸ | DRD2 | P14416 | 4/20 | 0.37 |
| ▸ | DRD1 | P21728 | 2/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15068838 | 0.91 | SUV39H2 (0.40) | KDM4EGAANPC1ALDH1A1MAPT | |
| SCHEMBL15069024 | 0.87 | NPC1 (0.41) | KDM4EGAANPC1ALDH1A1MAPT | |
| SCHEMBL15068931 | 0.86 | NPC1 (0.44) | KDM4EGAANPC1ALDH1A1MAPT | |
| SCHEMBL15067262 | 0.85 | ALDH1A1 (0.59) | KDM4EGAANPC1ALDH1A1MAPT | |
| SCHEMBL15069067 | 0.81 | NPC1 (0.40) | KDM4EGAANPC1ALDH1A1MAPT | |
| SCHEMBL15068949 | 0.81 | NPC1 (0.40) | KDM4EGAANPC1ALDH1A1MAPT | |
| SCHEMBL15069261 | 0.81 | NPC1 (0.48) | KDM4EGAANPC1ALDH1A1MAPT | |
| SCHEMBL15068562 | 0.81 | NPC1 (0.41) | KDM4EGAANPC1ALDH1A1MAPT | |
| SCHEMBL15067382 | 0.80 | NPC1 (0.48) | KDM4ENPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL15066423 | 0.80 | NPC1 (0.44) | KDM4EGAANPC1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013101974-A1 | COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY | PTC THERAPEUTICS, INC. (US) | 2013-07-04 | — | — | WO | disclosed |